Tbio EIF4EBP3 Eukaryotic translation initiation factor 4E-binding protein 3

Protein Summary

Description

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• O60516
• 4E-BP3

Gene Name

• EIF4EBP3

Ensembl ID

• ENST00000310331
• ENSP00000308472
• ENSG00000243056

Symbol

• 4EBP3
• 4E-BP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.66
tissue	0.62
histone modification site profile	0.59
transcription factor	0.56
transcription factor binding site profile	0.56

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Eukaryotic Translation Initiation Factor 4e-binding Protein 3

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Eukaryotic Translation Initiation Factor 4e-binding Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.51   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.51   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0