Tbio B4GALT3 Beta-1,4-galactosyltransferase 3

Protein Summary

Description

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• O60512
• D3DVG3
• O60910
• Q9BPZ4
• Q9H8T2
• Beta-1,4-GalTase 3

Gene Name

• B4GALT3

Ensembl ID

• ENST00000319769
• ENSP00000320965
• ENSG00000158850
• ENST00000367998
• ENSP00000356977
• ENST00000622395
• ENSP00000480428

Symbol

• beta4Gal-T3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
virus perturbation	0.85
disease perturbation	0.83
kinase perturbation	0.81
transcription factor binding site profile	0.8

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 3

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0