You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CDC40
Pre-mRNA-processing factor 17

Protein Summary
Description
Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing. Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307731
  • ENSP00000304370
  • ENSG00000168438
  • ENST00000368932
  • ENSP00000357928

Symbol
  • EHB3
  • PRP17
  • PRPF17
  • EHB3
  • PRP17
  • PRPF17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
histone modification site profile
0.74
virus perturbation
0.72
kinase perturbation
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.11   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.11   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0