Property Summary

NCBI Gene PubMed Count 31
Grant Count 14
R01 Count 9
Funding $906,090.18
PubMed Score 28.69
PubTator Score 11.43

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (11)

Disease log2 FC p
malignant mesothelioma -1.500 0.000
oligodendroglioma 1.100 0.012
psoriasis -1.400 0.000
atypical teratoid / rhabdoid tumor 1.700 0.000
glioblastoma 1.800 0.000
active Crohn's disease -1.338 0.006
active ulcerative colitis -1.271 0.022
pediatric high grade glioma 1.300 0.000
group 3 medulloblastoma -1.500 0.000
inflammatory breast cancer -1.300 0.008
COPD -1.400 0.003

Gene RIF (9)

PMID Text
25972535 Taken together, the findings suggest that vinexin beta modulates NS5A phosphorylation via its interaction with NS5A, thereby regulating hepatitis C virus replication, implicating vinexin beta in the viral life cycle.
25824575 Our findings revealed that Vinexin-beta acts as a novel modulator of ischaemic injury
20361963 Vinexin knockdown using siRNA delayed migration of both HaCaT human keratinocytes and A431 epidermoid carcinoma cells in scratch assay but did not affect cell proliferation.
19294487 Rhotekin forms a complex with vinexin and may play a role at focal adhesions.
17486060 Vinexin is enriched at the leading edge of migrating cells, lamellipodia and and focal adhesions in well-spread cells.
16923119 These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl.
15734736 phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta
15184391 vinexin is a novel substrate of ERK2 and may play roles in ERK-dependent cell regulation
12510380 regulates cytoskeletal organization and signal transduction--review

AA Sequence

MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGGYTPRRDAS      1 - 70
QHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSV     71 - 140
DRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFN    141 - 210
YRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELA    211 - 280
ELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPF    281 - 350
LGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG    351 - 420
EHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNEN    421 - 490
WYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGG    491 - 560
QTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDE    561 - 630
LELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV                                 631 - 671
//

Text Mined References (44)

PMID Year Title
25972535 2015 Vinexin ? Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.
25824575 2015 Vinexin-? deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22223895 2012 Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
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