Tbio ADCY9 Adenylate cyclase type 9

Protein Summary

Description

Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60503
• A7E2V5
• A7E2X2
• D3DUD1
• O60273
• Q4ZHT9
• Q4ZIR5
• Q9BWT4
• Q9UGP2

Gene Name

• ADCY9

Ensembl ID

• ENST00000294016
• ENSP00000294016
• ENSG00000162104

Symbol

• KIAA0520
• AC9
• ACIX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
transcription factor perturbation	0.96
biological process	0.95
molecular function	0.9
microRNA	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.22   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.22   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0