Tbio ACSL4 Long-chain-fatty-acid--CoA ligase 4

Protein Summary

Description

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• O60488
• D3DUY2
• O60848
• O60849
• Q5JWV8

Gene Name

• ACSL4

Ensembl ID

• ENST00000340800
• ENSP00000339787
• ENSG00000068366
• ENST00000348502
• ENSP00000262835
• ENST00000469796
• ENSP00000419171

Symbol

• ACS4
• FACL4
• LACS4
• ACS4
• FACL4
• LACS4
• MRX63
• MRX68

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
molecular function	0.91
microRNA	0.83
cellular component	0.78
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Ligase / Long-chain-fatty-acid--coa Ligase 4

DTO Classes

Protein / Enzyme / Ligase / Long-chain-fatty-acid--coa Ligase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.82   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.82   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0