Property Summary

NCBI Gene PubMed Count 35
PubMed Score 11.07
PubTator Score 52.06

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
ovarian cancer 8492 1.30316059483648E-7
sonic hedgehog group medulloblastoma 1482 1.1821358356688E-4
tuberculosis and treatment for 6 months 686 1.65551199728956E-4
psoriasis 6685 3.51570010131303E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 8.51916441760471E-4
lung cancer 4473 0.00322038482814861
Gaucher disease type 3 76 0.0046352613937207
Rheumatoid Arthritis 1171 0.00782823502037131
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0103920239185702
aldosterone-producing adenoma 664 0.0311325712448929

Expression

Synonym

Accession O60381 B3KVB7 Q8TBM1 Q8TE93 Q96AJ2
Symbols

Gene

PDB

2E6O   3QVE  

  Ortholog (11)

Gene RIF (24)

PMID Text
26660958 All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer.
26041766 Hbp1 plays a crucial role in regulating the timing of cortical neurogenesis by elongating the cell cycle and that it is essential for normal cortical development.
25666090 HBP1-mediated Wnt signaling is involved with the role of miR-155 in osteosarcoma progression.
24931370 miR-96/HBP1/Wnt/beta-catenin regulatory circuitry promotes the proliferation of glioma cell
24895061 HBP1 is a suppressor of cancer progression and a regulator of CTNNB1 gene transcription.
24762137 HBP1 is a novel target of the PI3K/FOXO pathway and controls cell proliferation in response to growth factors.
23613959 acetylation of TCF4E is a novel regulatory mechanism that diversifies the transcriptional output of Wnt/beta-catenin signaling
23249948 HBP1 represses the DNMT1 gene through binding a high-affinity site in the DNMT1 promoter.
22586168 Cis-acting regulatory polymorphisms acting on HBP1 contribute to the osteoarthritis association signal at chromosome 7q22.
20581871 HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence.
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AA Sequence

MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPT      1 - 70
QSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHII     71 - 140
ATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPST    141 - 210
VWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKL    211 - 280
TFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINFDDSGV    281 - 350
FDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKN    351 - 420
HSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKAL    421 - 490
AEEQKRLNPDCWKRKRTNSGSQQH                                                  491 - 514
//

Text Mined References (38)

PMID Year Title
26660958 2016 All Trans-Retinoic Acid Mediates MED28/HMG Box-Containing Protein 1 (HBP1)/?-Catenin Signaling in Human Colorectal Cancer Cells.
26041766 2015 Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression.
25666090 2015 miR-155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism.
24931370 2014 miR-96/HBP1/Wnt/?-catenin regulatory circuitry promotes glioma growth.
24895061 2014 HBP1 promoter methylation augments the oncogenic ?-catenin to correlate with prognosis in NSCLC.
24762137 2014 The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23859194 2013 Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells.
23613959 2013 Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex.
23249948 2013 HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence.
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