Property Summary

NCBI Gene PubMed Count 50
PubMed Score 37.66
PubTator Score 62.69

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Lipoidosis 19
Pancreatitis 97
Disease Target Count P-value
glioblastoma multiforme 347 2.47467631626498E-17
astrocytoma 1493 1.60992331060983E-13
lung carcinoma 2844 1.72360843163575E-11
pituitary cancer 1972 4.62051551390902E-8
malignant mesothelioma 3163 9.03904583438756E-8
lung cancer 4473 2.43403959465207E-6
psoriasis 6685 7.57687105162903E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.48321229543215E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 2.81743584726085E-4
cystic fibrosis 1670 6.48040286667886E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00132141919720317
ovarian cancer 8492 0.0014208785087318
posterior fossa group A ependymoma 1511 0.00254145477000822
subependymal giant cell astrocytoma 2287 0.00328529013086158
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00971885824492086
Down syndrome 548 0.0246116289645203
Disease Target Count Z-score Confidence
Type 1 diabetes mellitus 104 0.0 2.0



Accession O60356 B2R5C4 O60357 Q6FGG3
Symbols P8


  Ortholog (7)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid

Gene RIF (40)

26617245 Nupr1 acts as a gene modifier of the effect of Kras(G12D)-induced senescence by regulating Dnmt1 expression and consequently genome-wide levels of DNA methylation.
26392315 Hepatitis B virus X (HBx) protein can modulate NUPR1 expression through the Smad4 pathway and NUPR1 has a role in hepatocellular carcinoma progression.
26173068 Mitochondrial respiratory defects and subsequent retrograde signaling, particularly the NUPR1-granulin pathway, play pivotal roles in liver cancer progression
26062422 Knockdown of Nupr1 inhibited the proliferation and migration of HepG2 hepatocellular carcinoma cells
25924802 Increase of NUPR1 protein expression is associated with endometrial cancer invasion.
25899918 Functional characterization of NUPR1L as a new p53-induced gene, which negatively regulates the protumoral factor NUPR1.
25126861 P8 and MEG3 mRNA levels were significantly lower in nonfunctioning and corticotroph adenomas compared with normal pituitary.
25056123 NUPR1 has been conserved throughout evolution, and over time it has undergone duplications and transpositions to form other transcriptional regulators.
24497499 Stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes.
24205110 The Nupr1 protein bound to chemically-damaged-DNA with a slightly larger affinity (0.4 microM), but in an enthalpically-driven process. Nupr1 showed different interacting regions in the formed complexes with Nupr1 or DNA

AA Sequence

QNSERKKRGARR                                                               71 - 82

Text Mined References (53)

PMID Year Title
26617245 2015 Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.
26392315 2015 Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway.
26173068 2015 Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression.
26062422 2015 [Nuclear protein 1 knockdown inhibits proliferation and migration of HepG2 cells].
25924802 2015 Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion.
25899918 2015 Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1.
25201988 2014 Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
25126861 2014 Expression analysis of GADD45?, MEG3, and p8 in pituitary adenomas.
25056123 2014 Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins.
24497499 2014 Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes.