Property Summary

NCBI Gene PubMed Count 30
PubMed Score 38.18
PubTator Score 24.98

Knowledge Summary

Patent (7,982)

TINX Plot

  Disease Sources (5)

Disease Target Count P-value
posterior fossa group B ependymoma 1530 3.44305403322963E-14
pilocytic astrocytoma 3086 1.98740708133991E-8
pediatric high grade glioma 2712 9.00885664188742E-5
psoriasis 6685 1.44882174375174E-4
malignant mesothelioma 3163 2.90081479782359E-4
osteosarcoma 7933 3.14263960968206E-4
glioblastoma 5572 0.00178911279650447
group 3 medulloblastoma 2254 0.00354907372325065
primitive neuroectodermal tumor 3031 0.00918248337439384
ovarian cancer 8492 0.0231544688435171
atypical teratoid / rhabdoid tumor 4369 0.0295130310078297
aldosterone-producing adenoma 664 0.0372314181842744
acute myeloid leukemia 785 0.046392773077383
Disease Target Count Z-score Confidence
Nonsyndromic congenital nail disorder 1 3 4.579 2.3

Expression

  Differential Expression (13)

Synonym

Accession O60353 B4DRN0 Q6N0A5 Q6P9C3 Q8WXR9 Fz-6
Symbols FZ6
FZ-6
HFZ6
NDNC10

Gene

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (18)

PMID Text
25772759 we found that FZD6 expression was negatively regulated by miR199a5p
24816679 The rs3808553 of FZD6 is obviously associated with neural tube defects in Han population of northern China
24657404 This study confirms our speculation that down-regulation of FZD6 by beta-Carotene is causally related to the observed up-regulation of cancer related genes
24500924 DVL is a master regulator of FZD6/G-protein signaling
23748645 It is associated with poor prognosis in glioblastoma patients.
23374899 FZD6 should be screened for pachyonychia congenita as it is a candidate gene for hereditary nail dysplasias.
22861124 sequence analysis revealed a novel homozygous missense mutation (c.1266G>A; p.Gly422Asp) located in the transmembrane domain of the protein FZD6 in individuals of a consanguineous family exhibiting features of nail dysplasia
22249030 When transplanted into immunodeficient mice, neuroblastoma cells expressing the Fzd6 marker grow more aggressively than their Fzd6 negative counterparts. Fzd6 is a new surface marker of aggressive neuroblastoma cells with stem cell-like features.
22211385 The present results emphasize the role of FZD6 mutation in Wnt pathways in nail development.
22078044 Mutations in this gene cause nail dysplasia. Review.
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AA Sequence

MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECS      1 - 70
PNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPH     71 - 140
TEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCL    141 - 210
CATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNK    211 - 280
ACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEG    281 - 350
DNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF    351 - 420
SGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLMTLIVGISA    421 - 490
VFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHKKKHYKPSSHKLKVISKSMGT    491 - 560
STGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREVKADGASTPRLREQDCGEPASPAASISRLSG    561 - 630
EQVDGKGQAGSVSESARSEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGG    631 - 700
GCHSDT                                                                    701 - 706
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Text Mined References (35)

PMID Year Title
25772759 2015 FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer.
24816679 2014 Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population.
24657404 2014 Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung.
24500924 2014 Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.
24431302 2014 Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
23748645 2014 Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining.
23374899 2013 Recessive mutations in the gene encoding frizzled 6 cause twenty nail dystrophy--expanding the differential diagnosis for pachyonychia congenita.
22861124 2013 A novel missense mutation in the gene FZD6 underlies autosomal recessive nail dysplasia.
22575959 2012 ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
22249030 2011 Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.
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