Tbio | Trafficking kinesin-binding protein 2 |
May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.
Comments
Disease | Target Count | P-value |
---|---|---|
lung adenocarcinoma | 2714 | 3.69632283713628E-17 |
psoriasis | 6685 | 5.59013586672044E-9 |
ovarian cancer | 8492 | 3.57212042464523E-7 |
ulcerative colitis | 2087 | 4.50360916406869E-5 |
Pick disease | 1893 | 2.65787983909864E-4 |
osteosarcoma | 7933 | 5.96716694768877E-4 |
atypical teratoid/rhabdoid tumor | 1095 | 7.64142286357675E-4 |
Rheumatoid Arthritis | 1171 | 9.4899122078902E-4 |
subependymal giant cell astrocytoma | 2287 | 0.0139960200237181 |
mucosa-associated lymphoid tissue lymphoma | 480 | 0.0355127431678885 |
Disease | log2 FC | p |
---|---|---|
Rheumatoid Arthritis | 1.200 | 0.001 |
psoriasis | -1.200 | 0.000 |
osteosarcoma | -1.371 | 0.001 |
atypical teratoid/rhabdoid tumor | -1.200 | 0.001 |
lung adenocarcinoma | -1.100 | 0.000 |
subependymal giant cell astrocytoma | 1.291 | 0.014 |
Pick disease | 1.400 | 0.000 |
mucosa-associated lymphoid tissue lympho... | 1.268 | 0.036 |
ulcerative colitis | -1.200 | 0.000 |
ovarian cancer | -2.200 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Chicken | OMA Inparanoid |
Anole lizard | OMA Inparanoid |
Xenopus | OMA Inparanoid |
PMID | Text |
---|---|
26658612 | Full-length APC promotes assembly of the Miro-1/Milton-2 complex. |
25653102 | This study showed that the TRAK2 was more prevalent in dendrites of hippocampal neurons. In cortical neurons, TRAK2 was equally distributed between axons and dendrites. |
23395375 | The results of this study established a key role for mammalian TRAK2 proteins in axonal and dendritic targeting of mitochondria. |
20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
19913121 | Observational study of gene-disease association. (HuGE Navigator) |
19103291 | These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons. |
16895905 | Binds to Kir2.1 and facilitates trafficking of this channel to the cell surface. |
16835241 | analysis of the GRIF-1 binding domain of the kinesin, KIF5C, which substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes |
15644324 | GRIF-1 and OIP106 have roles in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1 |
12034717 | identification, molecular cloning and characterization |
MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELVSLLEEQLPQYRLKVDTLFLYENQDWT 1 - 70 QSPHQRQHASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRN 71 - 140 HVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQL 141 - 210 EMLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRY 211 - 280 QEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKEL 281 - 350 RSRSGPTAHLYFSQSYGAFTGESLAAEIEGTMRKKLSLDEESSLFKQKAQQKRVFDTVRIANDTRGRSIS 351 - 420 FPALLPIPGSNRSSVIMTAKPFESGLQQTEDKSLLNQGSSSEEVAGSSQKMGQPGPSGDSDLATALHRLS 421 - 490 LRRQNYLSEKQFFAEEWQRKIQVLADQKEGVSGCVTPTESLASLCTTQSEITDLSSASCLRGFMPEKLQI 491 - 560 VKPLEGSQTLYHWQQLAQPNLGTILDPRPGVITKGFTQLPGDAIYHISDLEEDEEEGITFQVQQPLEVEE 561 - 630 KLSTSKPVTGIFLPPITSAGGPVTVATANPGKCLSCTNSTFTFTTCRILHPSDITQVTPSSGFPSLSCGS 631 - 700 SGSSSSNTAVNSPALSYRLSIGESITNRRDSTTTFSSTMSLAKLLQERGISAKVYHSPISENPLQPLPKS 701 - 770 LAIPSTPPNSPSHSPCPSPLPFEPRVHLSENFLASRPAETFLQEMYGLRPSRNPPDVGQLKMNLVDRLKR 771 - 840 LGIARVVKNPGAQENGRCQEAEIGPQKPDSAVYLNSGSSLLGGLRRNQSLPVIMGSFAAPVCTSSPKMGV 841 - 910 LKED 911 - 914 //
PMID | Year | Title |
---|---|---|
26658612 | 2016 | APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane. |
25653102 | 2015 | Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons. |
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
23395375 | 2013 | TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
20230862 | 2010 | Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. |
19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
19103291 | 2009 | GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. |
16895905 | 2006 | Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1. |
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