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Tbio Trafficking kinesin-binding protein 2

May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

 Comments

Property Summary

NCBI Gene PubMed Count 22
PubMed Score 13.04
PubTator Score 11.80

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Liver Cirrhosis, Experimental 769 0.0 0.0
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8

Expression

  Differential Expression (10)

Disease log2 FC p
atypical teratoid / rhabdoid tumor -1.100 5.1e-03
lung adenocarcinoma -1.100 3.7e-17
mucosa-associated lymphoid tissue lympho... 1.268 3.6e-02
osteosarcoma -1.371 6.0e-04
ovarian cancer -1.900 8.1e-06
Pick disease 1.400 2.7e-04
psoriasis -1.100 1.0e-06
Rheumatoid arthritis 1.200 9.5e-04
subependymal giant cell astrocytoma 1.291 1.4e-02
ulcerative colitis -1.100 2.2e-06

Synonym

Accession O60296 E7EV21 Q8WVH7 Q96NS2 Q9C0K5 Q9C0K6
Symbols GRIF1
MILT2
OIP98
CALS-C
GRIF-1
ALS2CR3

Gene

TRAK2

PANTHER Protein Class (1)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (11)

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 GO Function (5)

 GO Component (8)

 GO Process (7)

 Compartment GO Term (26)

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 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (2)

Protein-protein Interaction (26)

ACAD11   OGT   KLC1   KLC2   KLC4   PLK1   CKAP2   KIF1B   KIF5C   KIF5B   KIF5A   RHOT1   GSK3B   GSK3A   MAP7D3   TRAK1   FAM83D   PRKAA1   TRIM71   FOXK1   NEDD1   PRKAB2   SNAPIN   DTNBP1   TEDC1   CARD19  

Gene RIF (10)

AA Sequence 

MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELVSLLEEQLPQYRLKVDTLFLYENQDWT      1 - 70
QSPHQRQHASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRN     71 - 140
HVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQL    141 - 210
EMLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRY    211 - 280
QEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKEL    281 - 350
RSRSGPTAHLYFSQSYGAFTGESLAAEIEGTMRKKLSLDEESSLFKQKAQQKRVFDTVRIANDTRGRSIS    351 - 420
FPALLPIPGSNRSSVIMTAKPFESGLQQTEDKSLLNQGSSSEEVAGSSQKMGQPGPSGDSDLATALHRLS    421 - 490
LRRQNYLSEKQFFAEEWQRKIQVLADQKEGVSGCVTPTESLASLCTTQSEITDLSSASCLRGFMPEKLQI    491 - 560
VKPLEGSQTLYHWQQLAQPNLGTILDPRPGVITKGFTQLPGDAIYHISDLEEDEEEGITFQVQQPLEVEE    561 - 630
KLSTSKPVTGIFLPPITSAGGPVTVATANPGKCLSCTNSTFTFTTCRILHPSDITQVTPSSGFPSLSCGS    631 - 700
SGSSSSNTAVNSPALSYRLSIGESITNRRDSTTTFSSTMSLAKLLQERGISAKVYHSPISENPLQPLPKS    701 - 770
LAIPSTPPNSPSHSPCPSPLPFEPRVHLSENFLASRPAETFLQEMYGLRPSRNPPDVGQLKMNLVDRLKR    771 - 840
LGIARVVKNPGAQENGRCQEAEIGPQKPDSAVYLNSGSSLLGGLRRNQSLPVIMGSFAAPVCTSSPKMGV    841 - 910
LKED                                                                      911 - 914
//

Text Mined References (25)

PMID Year Title