| Tbio | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Esophageal Neoplasms | 69 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 8.3e-41 |
| Breast cancer | 3578 | 9.4e-31 |
| periodontitis | 293 | 7.2e-21 |
| non-small cell lung cancer | 2890 | 9.1e-15 |
| ependymoma | 4679 | 9.1e-10 |
| medulloblastoma, large-cell | 6241 | 2.0e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 8.7e-06 |
| breast carcinoma | 1638 | 1.0e-05 |
| osteosarcoma | 7950 | 1.1e-04 |
| adult high grade glioma | 3801 | 2.0e-04 |
| glioblastoma | 5792 | 2.3e-04 |
| group 3 medulloblastoma | 4104 | 3.2e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.0e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.3e-02 |
| primitive neuroectodermal tumor | 3035 | 1.4e-02 |
| invasive ductal carcinoma | 2951 | 2.5e-02 |
| non primary Sjogren syndrome sicca | 891 | 2.7e-02 |
| astrocytic glioma | 2597 | 2.9e-02 |
| interstitial cystitis | 2312 | 2.9e-02 |
| lung cancer | 4740 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bloom syndrome | 29 | 3.327 | 1.7 |
| Gilles de la Tourette syndrome | 47 | 3.154 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.300 | 2.0e-04 |
| astrocytic glioma | -1.100 | 2.9e-02 |
| atypical teratoid / rhabdoid tumor | -1.800 | 8.7e-06 |
| Breast cancer | -1.900 | 9.4e-31 |
| breast carcinoma | -1.100 | 1.0e-05 |
| ependymoma | -1.700 | 9.1e-10 |
| glioblastoma | -1.200 | 2.3e-04 |
| group 3 medulloblastoma | -1.600 | 3.2e-04 |
| interstitial cystitis | 1.100 | 2.9e-02 |
| intraductal papillary-mucinous carcinoma... | -1.500 | 2.0e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.200 | 1.3e-02 |
| invasive ductal carcinoma | -1.100 | 2.5e-02 |
| lung cancer | -1.100 | 3.8e-02 |
| medulloblastoma, large-cell | -2.100 | 2.0e-06 |
| non primary Sjogren syndrome sicca | 1.200 | 2.7e-02 |
| non-small cell lung cancer | -1.202 | 9.1e-15 |
| osteosarcoma | -1.226 | 1.1e-04 |
| periodontitis | 1.100 | 7.2e-21 |
| primitive neuroectodermal tumor | -1.200 | 1.4e-02 |
| psoriasis | -1.100 | 8.3e-41 |
