| Tbio | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).
Comments
| Disease | Target Count |
|---|---|
| Esophageal Neoplasms | 67 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bloom syndrome | 30 | 3.307 | 1.7 |
| Gilles de la Tourette syndrome | 47 | 3.168 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.100 | 0.029 |
| osteosarcoma | -1.516 | 0.006 |
| ependymoma | -1.700 | 0.000 |
| glioblastoma | -1.700 | 0.000 |
| group 3 medulloblastoma | -2.700 | 0.000 |
| periodontitis | 1.100 | 0.000 |
| atypical teratoid / rhabdoid tumor | -1.800 | 0.000 |
| medulloblastoma, large-cell | -3.100 | 0.000 |
| primitive neuroectodermal tumor | -2.200 | 0.003 |
| non-small cell lung cancer | -1.202 | 0.000 |
| intraductal papillary-mucinous carcinoma... | -1.500 | 0.002 |
| intraductal papillary-mucinous neoplasm ... | -1.200 | 0.013 |
| lung cancer | -1.100 | 0.038 |
| breast carcinoma | -1.100 | 0.000 |
| interstitial cystitis | 1.100 | 0.029 |
| pediatric high grade glioma | -1.700 | 0.000 |
| non primary Sjogren syndrome sicca | 1.200 | 0.027 |
| non-inflammatory breast cancer | -2.700 | 0.000 |
| invasive ductal carcinoma | -1.100 | 0.025 |
| psoriasis | -1.100 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| Zebrafish | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 23403885 | GNG7 is a highly specific promoter methylated gene associated with head and neck cancer. |
| 22183866 | Loss of GNG7 protein expression is a frequent event in head and neck cancer with hypermethylation of the promoter region of GNG7 being probably the mechanism for the observed inactivation. |
| 20543539 | Reduced expression of G-gamma 7 is associated with the histological grade of EHCC and may prove to be a useful marker for predicting the prognosis of human EHCC. |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18219292 | GNG7 suppression represents a new prognostic indicator in cases of oesophageal cancer. |
| PMID | Year | Title |
|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 24324551 | 2013 | Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. |
| 23533145 | 2013 | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. |
| 23403885 | 2013 | Identification of guanine nucleotide-binding protein ?-7 as an epigenetically silenced gene in head and neck cancer by gene expression profiling. |
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| 22183866 | 2012 | Loss of protein expression and recurrent DNA hypermethylation of the GNG7 gene in squamous cell carcinoma of the head and neck. |
| 20543539 | 2010 | Human G-protein gamma 7 in extrahepatic cholangiocarcinoma and its clinicopathological significance. |
| 20458337 | MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. | |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
| More... |
