Property Summary

NCBI Gene PubMed Count 34
PubMed Score 130.11
PubTator Score 97.86

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
acute quadriplegic myopathy 1157 3.34059571989773E-6
Duchenne muscular dystrophy 602 4.31516623411064E-6
malignant mesothelioma 3163 9.91780175397808E-6
ovarian cancer 8492 2.26876128338664E-5
Amyotrophic Lateral Sclerosis 432 6.25028956185381E-5
Atopic dermatitis 944 1.61502655300358E-4
dermatomyositis 967 7.55332042548274E-4
invasive ductal carcinoma 2950 0.00254861890461139
pancreatic cancer 2300 0.00394397259458421
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0058170358488706
lung cancer 4473 0.00622362697996163
Breast cancer 3099 0.0280468531488129
primary pancreatic ductal adenocarcinoma 1271 0.0322920638601938
active Crohn's disease 918 0.0389555196331144
Disease Target Count Z-score Confidence
Lice infestation 16 4.201 2.1
Visual epilepsy 4 3.44 1.7
Cancer 2346 3.375 1.7


  Differential Expression (14)


Accession O60238 B0AZS9 Q5JW63 Q8NF87
Symbols NIX


  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

 GWAS Trait (1)

Gene RIF (15)

25753537 regulates mitophagy during hypoxia, whereas NIX is required for mitophagy during development of the erythroid lineage.
22984526 Nix protein positively regulates NF-kappaB activation in gliomas
22292033 The physical interaction of Mieap, BNIP3 and NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
21264228 mitochondrial ROS and NIX are essential factors for Mieap-induced accumulation of lysosome-like organelles within mitochondria
20819778 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20010802 Nix functions as an autophagy receptor, which mediates mitochondrial clearance after mitochondrial damage and during erythrocyte differentiation
19273585 Results suggest that hypoxia-induced autophagy via BNIP3 and BNIP3L is clearly a survival mechanism that promotes tumor progression.
19064571 Observational study of gene-disease association. (HuGE Navigator)
18670647 Homozygous deletions in a number of biologically important genes were found in prostate cancer cell lines, including PPP2R2A and BNIP3L identified in this study.
18551130 Results report that oxygen deprivation can activate the autophagic pathway in human cancer cell lines via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

AA Sequence

LSTPSASTY                                                                 211 - 219

Text Mined References (40)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
25753537 2015 Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22984526 2012 Nix protein positively regulates NF-?B activation in gliomas.
22645275 2012 Identification of novel ATP13A2 interactors and their role in ?-synuclein misfolding and toxicity.
22292033 2012 BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21264228 2011 Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria.