Property Summary

NCBI Gene PubMed Count 26
PubMed Score 16.46
PubTator Score 11.74

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
Breast cancer 3099 1.68067385709029E-22
breast carcinoma 1614 3.86558725418249E-17
ovarian cancer 8492 8.83578621673832E-13
pilocytic astrocytoma 3086 2.84661822964605E-9
psoriasis 6685 3.84039364956212E-8
medulloblastoma, large-cell 6234 5.2380349556847E-7
colon cancer 1475 8.05041413248708E-7
pediatric high grade glioma 2712 1.70544796228814E-6
sonic hedgehog group medulloblastoma 1482 2.38941201012922E-6
glioblastoma 5572 2.90183407096643E-5
lung cancer 4473 3.31330912745014E-5
primitive neuroectodermal tumor 3031 1.08443746692551E-4
osteosarcoma 7933 1.45165719983651E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 4.47558442473288E-4
atypical teratoid / rhabdoid tumor 4369 6.18999986790556E-4
invasive ductal carcinoma 2950 9.09431103639366E-4
Pick disease 1893 0.00162967535727791
interstitial lung disease 292 0.00195570237560636
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00321490923061004
subependymal giant cell astrocytoma 2287 0.00550132716734094
active ulcerative colitis 477 0.00637606559067656
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00793767322026104
limb girdle muscular dystrophy 2I 56 0.0101312910428566
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.034547032595487

Expression

Synonym

Accession O60237 A8MYF5 B7ZMN6 Q2TAI8 Q5T506 Q5VUK2 Q8N179 Q9HCB7 Q9HCB8
Symbols MYPT2
PP1bp55

Gene

  Ortholog (8)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
C. elegans OMA Inparanoid

Gene RIF (6)

PMID Text
23640410 PPP1R12B is associated with childhood asthma in a Russian population.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20198315 Observational study of gene-disease association. (HuGE Navigator)
19851296 Observational study of gene-disease association. (HuGE Navigator)
18782776 analysis of the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase
16431080 Results describe the characterization and function of MYPT2, a target subunit of myosin phosphatase in heart.

AA Sequence

MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGD      1 - 70
TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIA     71 - 140
EYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIED    141 - 210
VRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRN    211 - 280
KLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEM    281 - 350
EEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS    351 - 420
SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISALLDNKDKEREN    421 - 490
KSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHK    491 - 560
SQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAES    561 - 630
LRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATE    631 - 700
AGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTT    701 - 770
TAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG    771 - 840
GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADI    841 - 910
KSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQRLKDENGALIRVISKL    911 - 980
SK                                                                        981 - 982
//

Text Mined References (27)

PMID Year Title
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
25814554 2015 Phospho-tyrosine dependent protein-protein interaction network.
24778558 2013 RTN4 and FBXL17 Genes are Associated with Coronary Heart Disease in Genome-Wide Association Analysis of Lithuanian Families.
23936387 2013 A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
23640410 2013 Validation of PPP1R12B as a candidate gene for childhood asthma in Russians.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
20801872 2010 Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20198315 2010 Association of genetic variants with hemorrhagic stroke in Japanese individuals.
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