Property Summary

NCBI Gene PubMed Count 20
Grant Count 22
R01 Count 10
Funding $5,489,391.47
PubMed Score 192.58
PubTator Score 42.87

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (7)

Disease log2 FC p
esophageal adenocarcinoma -2.900 0.021
psoriasis 7.600 0.000
cutaneous lupus erythematosus 1.900 0.020
osteosarcoma 1.922 0.000
non-small cell lung cancer 1.989 0.000
nasopharyngeal carcinoma -1.600 0.000
spina bifida -2.254 0.045

Gene RIF (11)

PMID Text
26297835 HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas
23192872 H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin are activated by matriptase in addition to HAT and TMPRSS2 and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity.
22558251 TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.
22245154 HAT cleaves proMSP at the physiological activation site
22023801 results suggest that HAI-1 functions as a physiological regulator of HAT by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAT)
21994442 Human HAT cleaved severe acute respiratory syndrome coronavirus spike protein at R667, as determined by mutagenesis and mass spectrometry.
16973594 TMPRSS2 and HAT are candidates for proteolytic activation of influenza viruses in vivo
16336275 HAT induces amphiregulin production through the PAR-2 mediated ERK pathway, and then causes amphiregulin release by a TACE-dependent mechanism
16199437 results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts
15102084 HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis.
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AA Sequence

MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPAT      1 - 70
QEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLR     71 - 140
QMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAH    141 - 210
HCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLEN    211 - 280
SVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSG    281 - 350
MLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI      351 - 418
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Text Mined References (21)

PMID Year Title
26297835 2016 Cell Surface Human Airway Trypsin-Like Protease Is Lost During Squamous Cell Carcinogenesis.
24227843 2014 TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
23536651 2013 TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23192872 2013 Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.
22558251 2012 Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
22245154 2012 Activation of macrophage-stimulating protein by human airway trypsin-like protease.
22023801 2012 Hepatocyte growth factor activator inhibitor type 1 inhibits protease activity and proteolytic activation of human airway trypsin-like protease.
21994442 2011 Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.
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