Tbio SSX4 Protein SSX4

Protein Summary

Description

Could act as a modulator of transcription. The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60224
• A8MYD4
• B2RPE3
• Q3SYD4
• Q5JQZ0
• Q9UJU9

Gene Name

• SSX4

Ensembl ID

• ENST00000595235
• ENSP00000469394
• ENSG00000269791
• ENST00000595689
• ENSP00000469011
• ENSG00000268009
• ENST00000619890
• ENSP00000481765
• ENST00000620320
• ENSP00000483262

Symbol

• SSX4A
• CT5.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.46
protein complex	0.4
disease	0.37
biological term	0.35
PubMedID	0.24

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein Ssx4

Protein / Nucleic Acid Binding / Protein Ssx4

DTO Classes

Protein / Nucleic Acid Binding / Protein Ssx4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.08   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.08   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0