Tclin PDE6D Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Protein Summary

Description

Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• O43924
• O43250
• GMP-PDE delta

Gene Name

• PDE6D

Ensembl ID

• ENST00000287600
• ENSP00000287600
• ENSG00000156973

Symbol

• PDED
• PDED
• JBTS22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
transcription factor perturbation	0.84
transcription factor binding site profile	0.8
disease perturbation	0.79
molecular function	0.73

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphodiesterase / Retinal Rod Rhodopsin-sensitive Cgmp 3',5'-cyclic Phosphodiesterase Subunit Delta

DTO Classes

Protein / Enzyme / Hydrolase / Phosphodiesterase / Retinal Rod Rhodopsin-sensitive Cgmp 3',5'-cyclic Phosphodiesterase Subunit Delta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.53   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.53   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 122

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1