Property Summary

NCBI Gene PubMed Count 28
Grant Count 5
R01 Count 5
Funding $180,362.3
PubMed Score 29.88
PubTator Score 9.53

Knowledge Summary


No data available


  Differential Expression (3)

Disease log2 FC p
Breast cancer 2.700 0.029
non primary Sjogren syndrome sicca 1.200 0.014
ovarian cancer 1.100 0.001


Accession O43924 O43250 GMP-PDE delta
Symbols PDED


PANTHER Protein Class (2)


5E8F   1KSG   1KSH   1KSJ   3T5G   3T5I   4JHP   4JV6   4JV8   4JVB   4JVF   5E80   5F2U  

Gene RIF (4)

24166846 Study identifies PDE6D as a novel Joubert syndrome gene and provides the first evidence of prenyl-binding-dependent trafficking in ciliopathies.
23559067 RPGR is acting as a scaffold protein recruiting cargo-loaded PDE6D and Arl3 to release lipidated cargo into cilia.
23150559 findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins
22179043 Data show that PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane.

AA Sequence

STSRVRLFYV                                                                141 - 150

Text Mined References (31)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
25519916 2014 The EHEC-host interactome reveals novel targets for the translocated intimin receptor.
25416956 2014 A proteome-scale map of the human interactome network.
24401286 2014 Prenylation defects in inherited retinal diseases.
24166846 2014 A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.
23698361 2013 Small molecule inhibition of the KRAS-PDE? interaction impairs oncogenic KRAS signalling.
23568457 2013 Genetic variants associated with disordered eating.
23559067 2013 The interplay between RPGR, PDE? and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
23301619 2013 Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen.
23150559 2012 ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.