Tchem SLC28A2 Sodium/nucleoside cotransporter 2

Protein Summary

Description

Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Uniprot Accession IDs

• O43868
• A8K7F9
• O43239
• Q52LZ0

Gene Name

• SLC28A2

Ensembl ID

• ENST00000347644
• ENSP00000315006
• ENSG00000137860

Symbol

• CNT2
• CNT2
• HCNT2
• SPNT1
• HsT17153

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
protein domain	0.85
phenotype	0.58
PubMedID	0.46
chemical	0.45

Protein Classes

PANTHER Classes

Protein / Transporter / Sodium/nucleoside Cotransporter 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc28 And Slc29 Families Of Nucleoside Transporters / Slc28 Family / Sodium/nucleoside Cotransporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.71   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.71   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0