Property Summary

NCBI Gene PubMed Count 18
PubMed Score 41.43
PubTator Score 24.04

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Myocardial Ischemia 169
Disease Target Count P-value
psoriasis 6685 1.24637471593738E-34
posterior fossa group B ependymoma 1530 3.77443117731056E-10
atypical teratoid/rhabdoid tumor 1095 1.38133633844996E-6
adult high grade glioma 2148 1.52240202777983E-6
group 4 medulloblastoma 1875 1.53332863182646E-4
Multiple myeloma 1328 1.68449361552391E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0033139499125767
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00361977662783775
astrocytic glioma 2241 0.00478743286891372
ovarian cancer 8492 0.00582612631325348
ductal carcinoma in situ 1745 0.00952872349804245
primitive neuroectodermal tumor 3031 0.0125309118051943
Waldenstrons macroglobulinemia 765 0.0175673722147705
medulloblastoma, large-cell 6234 0.0255270124671081
oligodendroglioma 2849 0.0260262644769954
glioblastoma 5572 0.0267447104324112
subependymal giant cell astrocytoma 2287 0.0389753311741084
Breast cancer 3099 0.0447011503941432
Disease Target Count Z-score Confidence
Pasteurellosis 12 3.097 1.5

Expression

Gene

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (5)

PMID Text
24391510 Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa/ARPP19 and Cdk substrate dephosphorylation during mitotic exit.
24211627 Overexpressed ENSA suppresses tumor growth in an established hepatic cell line whereas hypermethylated ENSA might help maintain liver cancer initiating cells.
14728987 The ENSA gene on 1q21 produces several alternatively spliced transcripts, and is located within a region linked with T2DM in diverse populations including the Pima Indians
14728986 We mapped ENSA in silico to chromosome 1q21 near a confirmed type 2 diabetes susceptibility locus, and derived the genomic structure of four exons and three introns.
11771735 The considerably decreased alpha-endosulfine could result in the continuous opening of K(ATP) channels and the subsequent decrease of neurotransmitters release associated with cognition in Down Syndrome.

AA Sequence

MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDY      1 - 70
NMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE                        71 - 121
//

Text Mined References (27)

PMID Year Title
24391510 2014 PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24211627 2013 ENSA expression correlates with attenuated tumor propagation in liver cancer.
23585552 2013 Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
21044950 2011 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
18973346 2008 Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha.
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