Property Summary

NCBI Gene PubMed Count 22
PubMed Score 16.63
PubTator Score 6.24

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Peripheral Neuropathy 303
Disease Target Count P-value
breast carcinoma 1614 1.17201622956166E-41
Breast cancer 3099 4.12726238513006E-19
non-small cell lung cancer 2798 1.41893103090763E-17
lung adenocarcinoma 2714 1.4968314485869E-11
ovarian cancer 8492 1.55889944536343E-9
lung carcinoma 2844 5.02243225248563E-8
psoriasis 6685 6.23906526373599E-8
lung cancer 4473 8.85599640827499E-7
Duchenne muscular dystrophy 602 8.95578459075632E-5
medulloblastoma, large-cell 6234 1.32508896406063E-4
pituitary cancer 1972 1.40178496986381E-4
invasive ductal carcinoma 2950 0.0015938487959125
pilocytic astrocytoma 3086 0.00178103316695849
ulcerative colitis 2087 0.00236698234840462
ductal carcinoma in situ 1745 0.00263745247507934
sarcoidosis 368 0.00374312365117099
adrenocortical carcinoma 1427 0.00756836588412088
colon cancer 1475 0.0126131025457917
mucosa-associated lymphoid tissue lymphoma 480 0.0141507396793818
Multiple myeloma 1328 0.0227415829095578
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0313072529424629
severe Alzheimer's disease 49 0.0338825184433273
active Crohn's disease 918 0.041383168276494
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.049040312019546
Disease Target Count Z-score Confidence
X-linked nonsyndromic deafness 10 4.29 2.1
Mononeuropathy 3 3.113 1.6


  Differential Expression (24)


Accession O43736 B2R7X5 B4E062 Q6IBC9
Symbols E25A


  Ortholog (12)

Gene RIF (5)

26691219 ITM2A is a new biomarker of poor prognosis in ovarian cancer and a novel tumor suppressor that induces cell cycle arrest, acts as a chemosensitizer, and has therapeutic potential for ovarian cancer.
26125709 The upregulated gene with the largest effect size in ankylosing spondylitis was ITM2A, which plays a role in activation of T cells. (Meta-analysis)
25951193 ITM2A expression is positively regulated by PKA-CREB signaling and ITM2A expression interferes with autophagic flux by interacting with vacuolar ATPase.
24516404 our results show one of the first links between phenotypic variation in a population sample and an XCI-escaping locus and pinpoint ITM2A as a potential contributor to the sexual dimorphism in height
19541402 Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells.

AA Sequence


Text Mined References (23)

PMID Year Title
26691219 2016 Loss of ITM2A, a novel tumor suppressor of ovarian cancer through G2/M cell cycle arrest, is a poor prognostic factor of epithelial ovarian cancer.
26125709 2015 Meta-analysis of differentially expressed genes in ankylosing spondylitis.
25951193 2015 The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase.
25416956 2014 A proteome-scale map of the human interactome network.
24516404 2014 Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
23612905 2013 Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
19541402 Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells.
18391951 2008 Many sequence variants affecting diversity of adult human height.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.