Property Summary

NCBI Gene PubMed Count 13
PubMed Score 245.08
PubTator Score 17.23

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung cancer 4473 8.24417505856815E-5
ovarian cancer 8492 1.81662662392146E-4
Multiple myeloma 1328 2.49902815716181E-4
glioblastoma 5572 0.00146995988444587
group 3 medulloblastoma 2254 0.00567302614651673
Waldenstrons macroglobulinemia 765 0.0190451707458466
Breast cancer 3099 0.0259889637897627
astrocytic glioma 2241 0.0289216141186157


  Differential Expression (8)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.173 0.019
Multiple myeloma 1.956 0.000
astrocytic glioma -1.400 0.029
glioblastoma 1.300 0.001
lung cancer 1.900 0.000
Breast cancer 2.800 0.026
group 3 medulloblastoma 1.100 0.006
ovarian cancer 1.700 0.000


Accession O43715 B2R4Z7 Q5RKS5 Q6LCA7
Symbols WF-1



4XZS   4XZV  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
S.cerevisiae EggNOG Inparanoid

 GO Function (1)

Gene RIF (9)

26071602 crystal structures of free TRIAP1 and TRIAP1-SLMO1 complex reveal how the PRELI domain is chaperoned during import into the intermembrane mitochondrial space; structural resemblance of PRELI-like domain of SLMO1 with that of mammalian phoshatidylinositol transfer proteins suggest they share similar lipid transfer mechanisms
25998939 Results describe the upregulation of TRIAP1 in drugresistant breast cancer cells. Its experimental modulation changed breast tumor cells sensitivity to doxorubicin, thus confirming its role in drug resistance.
23931759 Loss of TRIAP1 or PRELI impairs the accumulation of Cardiolipin, facilitates the release of cytochrome c, and renders cells vulnerable to apoptosis upon intrinsic and extrinsic stimulation.
23684607 TRIAP1 is Conserved Specific Coregulators of the p21:PUMA Expression Ratio.
20877624 Observational study of gene-disease association. (HuGE Navigator)
19171422 Upregulated in at least 50% of multiple myeloma cases tested.
15735665 HSPC132 is p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway
15735003 Under specific conditions of stress, p53 regulates transcription of p53CSV and that p53CSV is one of the important players in the p53-mediated cell survival.
15735003 HSPC132 is p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway

AA Sequence

KPENSS                                                                     71 - 76

Text Mined References (18)

PMID Year Title
26071602 2015 Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.
25998939 2015 Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23931759 2013 TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid.
23684607 2013 A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21901158 2011 Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.