Property Summary

NCBI Gene PubMed Count 28
PubMed Score 51.41
PubTator Score 47.28

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
ovarian cancer 8492 1.54508551546747E-7
psoriasis 6685 0.00970340001819123
Disease Target Count Z-score Confidence
acute lymphocytic leukemia 25 5.174 2.6
T-cell leukemia 4 3.156 1.6
Disease Target Count
acute T cell leukemia 17


Accession O43711 Q96AD3
Symbols RNX


  Ortholog (5)

Species Source
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Xenopus OMA Inparanoid

Gene RIF (21)

26852660 Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.
24997618 Studies suggest that homeobox protein TLX3 expression is not an indicator for the prognosis of pediatric T cell acute lymphocytic leukemia (T-ALL).
24571118 Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 and SIL/TAL but a higher incidence of NKX2-5 expression than recorded in Western countries
22516263 The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1.
22366949 these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 as a tumor-suppressor gene in T-ALL
21617853 We found that 22 (21%) out of 110 clinical samples of bladder cancer showed the methylated pattern using the COBRA assay in TLX3. We found a correlation between TLX3 methylation and the sensitivity to cisplatin in the clinical samples by SDI test.
21374761 Results identify Tlx3 as a novel target for canonical Wnt signaling that confers somatic stem cells with a sensory neuron phenotype upon neural induction.
21225930 High TLX3/BCL11B fusion protein expression is associated with T/myeloid acute bilineal leukemia.
18368072 Aberrant HOX11L2 expression is associated with thymic adult T-cell acute lymphoblastic leukemia
18185524 five recurrent genomic deletions in TLX3 rearranged T-ALL; genome-wide overview of copy number changes in TLX3 rearranged T-ALL

AA Sequence

SSKVPAVTSLV                                                               281 - 291

Text Mined References (28)

PMID Year Title
26852660 2016 Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.
25428367 2014 Prediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes.
24997618 2014 The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia--a systematic review.
24571118 2016 NKX2-5, SIL/TAL and TLX3/HOX11L2 expression in Egyptian pediatric T-cell acute lymphoblastic leukemia.
22516263 2012 TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCR? gene expression.
22366949 2012 Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.
21617853 2011 Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer.
21374761 2011 Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3.
21225930 2011 Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion.
18368072 2008 Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group.