Tclin NDUFA2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• O43678
• D6RJD6
• Q6IAY8

Gene Name

• NDUFA2

Ensembl ID

• ENST00000252102
• ENSP00000252102
• ENSG00000131495
• ENST00000512088
• ENSP00000427220

Symbol

• B8
• CD14
• CIB8
• MC1DN13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
interacting protein	0.9
kinase perturbation	0.81
disease perturbation	0.74
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.83   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.83   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1