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  5. Mitochondrial import inner membrane translocase subunit TIM44

Tdark Mitochondrial import inner membrane translocase subunit TIM44

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.

This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016]

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Property Summary

NCBI Gene PubMed Count 17
Grant Count 15
R01 Count 10
Funding $637,044.78
PubMed Score 43.97
PubTator Score 12.38

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (2)

Disease Z-score Confidence
osteosarcoma 7,933
psoriasis 6,685

Expression

  Differential Expression (2)

Disease log2 FC p
psoriasis 1.600 0.000
osteosarcoma 1.475 0.000

Synonym

Accession O43615 A8K0R9 D6W664 Q8N193
Symbols TIM44

Gene

TIMM44

PANTHER Protein Class (2)

 Grant Application (15)

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PDB

2CW9  

 GO Function (2)

 GO Component (3)

 GO Process (2)

 Compartment GO Term (36)

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Pathway (3)

 UniProt Keyword (13)

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Gene RIF (3)

PMID Text
25749183 The Timm44 gene may be a new target for the treatment of type 2 diabetes
20877624 Observational study of gene-disease association. (HuGE Navigator)
20471030 This protein has been found differentially expressed in thalami from patients with schizophrenia.

AA Sequence 

MAAAALRSGWCRCPRRCLGSGIQFLSSHNLPHGSTYQMRRPGGELPLSKSYSSGNRKGFLSGLLDNVKQE      1 - 70
LAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSD     71 - 140
LGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKR    141 - 210
TEFAGDKFKEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRASRALT    211 - 280
DKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCENDIIPNVLEAMISGELDILKDWCYEATYSQ    281 - 350
LAHPIQQAKALGLQFHSRILDIDNVDLAMGKMMEQGPVLIITFQAQLVMVVRNPKGEVVEGDPDKVLRML    351 - 420
YVWALCRDQDELNPYAAWRLLDISASSTEQIL                                          421 - 452
//

Text Mined References (22)

PMID Year Title
26090338 2015 Mitochondrial Ion Channels in Cancer Transformation.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25749183 2015 Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes.
25666615 2015 The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13.
25416956 2014 A proteome-scale map of the human interactome network.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20471030 2010 Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
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