Protein Summary
Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
- ENST00000178638
- ENSP00000178638
- ENSG00000074410
- ENST00000344366
- ENSP00000343088
- CAXII
- CA-XII
- T18816
- HsT18816
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.98 | ||
kinase perturbation | 0.91 | ||
virus perturbation | 0.85 | ||
PubMedID | 0.84 | ||
gene perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.5 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 460 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.5 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 460 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3453
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 20