Property Summary

NCBI Gene PubMed Count 85
PubMed Score 51.46
PubTator Score 67.25

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Rheumatoid Arthritis 1171
Disease Target Count P-value
non-small cell lung cancer 2798 3.77624538564162E-13
ovarian cancer 8492 6.21812715378551E-11
head and neck cancer 270 3.25739503958295E-9
malignant mesothelioma 3163 6.30259621330411E-7
osteosarcoma 7933 2.10970096729509E-5
tuberculosis and treatment for 6 months 686 3.66465888442656E-5
interstitial cystitis 2299 3.87163056839262E-4
Disease Target Count Z-score Confidence
Multiple Sclerosis 498 0.0 2.0


  Differential Expression (7)

Disease log2 FC p
malignant mesothelioma -1.400 0.000
osteosarcoma -1.033 0.000
tuberculosis and treatment for 6 months -2.400 0.000
non-small cell lung cancer -1.093 0.000
interstitial cystitis 1.600 0.000
ovarian cancer -1.700 0.000
head and neck cancer 1.700 0.000


Accession O43557 A8K7M2 C9J5H4 O75476 Q6FHA1 Q8WVF8 Q96LD2
Symbols LTg



4EN0   4J6G   4KG8   4KGG   4KGQ   4RSU  

  Ortholog (12)

 GWAS Trait (1)

Gene RIF (72)

26448572 Serum LIGHT levels correlate with disease progression and severity in interstitial pneumonia patients with dermatomyositis.
26146063 proliferation and migration would be enhanced in Tca8113 cells with over-expressed TNFSF14
25789702 The tumor necrosis factor superfamily molecule LIGHT promotes keratinocyte activity and skin fibrosis.
25680454 LIGHT controls TSLP to drive pulmonary fibrosis.
25512551 regulation by NK cell licensing helps to safeguard against TNFSF14 production in response to healthy tissues.
25501580 LIGHT, via LTbetaR signaling, may contribute to exacerbation of airway neutrophilic inflammation through cytokine and chemokine production by bronchial epithelial cells.
25460501 LIGHT, a TNF superfamily member, is involved in T-cell homeostasis and erosive bone disease associated with rheumatoid arthritis.
25251281 The findings suggest a new molecular determinant of LIGHT-mediated pathogenic changes in human bronchial epithelial cells.
25087510 Crystal structures of LIGHT and the LIGHT:DcR3 complex reveal the structural basis for the DcR3-mediated neutralization of LIGHT.
24782592 TNFSF14 has an effect on the activation of basophils and eosinophils interacting with bronchial epithelial cells

AA Sequence

AGEKVVVRVLDERLVRLRDGTRSYFGAFMV                                            211 - 240

Text Mined References (87)

PMID Year Title
26977880 2016 Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade.
26646413 2016 Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
26448572 2015 Increased Serum LIGHT Levels Correlate with Disease Progression and Severity of Interstitial Pneumonia in Patients with Dermatomyositis: A Case Control Study.
26146063 2015 [The capacity of proliferation and migration is higher in Tca8113 cells with up-regulated TNFSF14 expression].
25789702 2015 The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis.
25680454 2015 Tumor necrosis factor superfamily 14 (LIGHT) controls thymic stromal lymphopoietin to drive pulmonary fibrosis.
25512551 2014 Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT.
25501580 2014 Lymphotoxin ? receptor signaling induces IL-8 production in human bronchial epithelial cells.
25460501 2014 LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease.
25251281 2015 LIGHT is a crucial mediator of airway remodeling.