Tbio CHST10 Carbohydrate sulfotransferase 10

Protein Summary

Description

Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• O43529
• Q53T18

Gene Name

• CHST10

Ensembl ID

• ENST00000264249
• ENSP00000264249
• ENSG00000115526
• ENST00000409701
• ENSP00000387309

Symbol

• HNK1ST
• HNK-1ST

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.75
small molecule perturbation	0.75
histone modification site profile	0.66
disease perturbation	0.62
PubMedID	0.51

Protein Classes

PANTHER Classes

Protein / Transferase / Carbohydrate Sulfotransferase 10

DTO Classes

Protein / Enzyme / Transferase / Carbohydrate Sulfotransferase 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.34   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.34   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0