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Tclin
KCNQ2
Potassium voltage-gated channel subfamily KQT member 2

Protein Summary
Description
Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873). The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344425
  • ENSP00000345523
  • ENSG00000075043
  • ENST00000344462
  • ENSP00000339611
  • ENST00000359125
  • ENSP00000352035
  • ENST00000360480
  • ENSP00000353668
  • ENST00000626839
  • ENSP00000486706

Symbol
  • EBN
  • BFNC
  • EBN1
  • ENB1
  • HNSPC
  • KV7.2
  • KCNA11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
protein domain
0.92
molecular function
0.88
PubMedID
0.73
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.87   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.87   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5