| Tbio | Forkhead box protein O3 |
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Adenocarcinoma of lung | 142 | 0.0 | 0.0 |
| Carcinoma, Adenoid Cystic | 99 | 0.0 | 0.0 |
| Carcinoma, Non-Small-Cell Lung | 107 | 0.0 | 0.0 |
| Diabetes Mellitus, Experimental | 108 | 0.0 | 0.0 |
| Encephalomyelitis, Autoimmune, Experimental | 8 | 0.0 | 0.0 |
| Obesity | 678 | 0.0 | 0.0 |
| Pulmonary Disease, Chronic Obstructive | 31 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 4.5e-12 |
| osteosarcoma | 7950 | 3.2e-06 |
| psoriasis | 6694 | 5.2e-05 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.3e-03 |
| astrocytoma | 1146 | 4.1e-03 |
| dermatomyositis | 966 | 4.1e-03 |
| chronic rhinosinusitis | 512 | 6.7e-03 |
| acute quadriplegic myopathy | 1158 | 1.0e-02 |
| cystic fibrosis and chronic rhinosinusitis | 214 | 2.0e-02 |
| spina bifida | 1074 | 3.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple Sclerosis | 540 | 0.0 | 0.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Premature ovarian failure | 65 | 3.963 | 2.0 |
| Muscular atrophy | 71 | 3.911 | 2.0 |
| diabetes mellitus | 1728 | 3.471 | 1.7 |
| Vascular disease | 319 | 3.465 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.170 | 1.0e-02 |
| astrocytoma | 1.500 | 4.1e-03 |
| chronic rhinosinusitis | -1.243 | 6.7e-03 |
| cystic fibrosis and chronic rhinosinusit... | -1.044 | 2.0e-02 |
| dermatomyositis | 1.700 | 4.1e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.400 | 1.3e-03 |
| osteosarcoma | -2.906 | 3.2e-06 |
| ovarian cancer | -2.100 | 4.5e-12 |
| psoriasis | -1.600 | 5.2e-05 |
| spina bifida | -1.155 | 3.7e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGG 1 - 70 GRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGA 71 - 140 AGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSI 141 - 210 RHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPES 211 - 280 ADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSS 281 - 350 SASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKG 351 - 420 SGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSD 421 - 490 PLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLS 491 - 560 ESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRS 561 - 630 ELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG 631 - 673 //
