Tclin CACNA1G Voltage-dependent T-type calcium channel subunit alpha-1G

Protein Summary

Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• O43497
• D6RA64
• E7EPR0
• O43498
• O94770
• Q19QY8
• Q19QY9
• Q19QZ0
• Q19QZ1
• Q19QZ2
• Q19QZ3
• Q19QZ4
• Q19QZ5
• Q19QZ6
• Q19QZ7
• Q19QZ8
• Q19QZ9
• Q19R00
• Q19R01
• Q19R02
• Q19R03
• Q19R04
• Q19R05
• Q19R06
• Q19R07
• Q19R08
• Q19R09
• Q19R10
• Q19R11
• Q19R12
• Q19R13
• Q19R15
• Q19R16
• Q19R17
• Q19R18
• Q2TAC4
• Q9NYU4
• Q9NYU5
• Q9NYU6
• Q9NYU7
• Q9NYU8
• Q9NYU9
• Q9NYV0
• Q9NYV1
• Q9UHN9
• Q9UHP0
• Q9ULU6
• Q9UNG7
• Q9Y5T2
• Q9Y5T3

Gene Name

• CACNA1G

Ensembl ID

• ENST00000352832
• ENSP00000339302
• ENSG00000006283
• ENST00000354983
• ENSP00000347078
• ENST00000358244
• ENSP00000350979
• ENST00000359106
• ENSP00000352011
• ENST00000360761
• ENSP00000353990
• ENST00000429973
• ENSP00000414388
• ENST00000442258
• ENSP00000409759
• ENST00000502264
• ENSP00000425522
• ENST00000503436
• ENSP00000427231
• ENST00000503485
• ENSP00000427238
• ENST00000503607
• ENSP00000426558
• ENST00000504076
• ENSP00000425153
• ENST00000505165
• ENSP00000422268
• ENST00000506406
• ENSP00000426313
• ENST00000507336
• ENSP00000420918
• ENST00000507510
• ENSP00000423112
• ENST00000507609
• ENSP00000423045
• ENST00000507896
• ENSP00000421518
• ENST00000510115
• ENSP00000427173
• ENST00000510366
• ENSP00000426814
• ENST00000511765
• ENSP00000427247
• ENST00000511768
• ENSP00000424664
• ENST00000512389
• ENSP00000426261
• ENST00000513689
• ENSP00000426172
• ENST00000513964
• ENSP00000425451
• ENST00000514079
• ENSP00000423317
• ENST00000514181
• ENSP00000425698
• ENST00000514717
• ENSP00000422407
• ENST00000515165
• ENSP00000426098
• ENST00000515411
• ENSP00000423155
• ENST00000515765
• ENSP00000426232

Symbol

• KIAA1123
• NBR13
• SCA42
• Cav3.1
• SCA42ND
• Ca(V)T.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
molecular function	0.86
transcription factor	0.83
PubMedID	0.76
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1g

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Calcium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1g

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1g

Protein / Transporter / Ion Channel / Calcium Channel / Voltage-gated Calcium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1g

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Cacna1g Subfamily / Voltage-dependent T-type Calcium Channel Subunit Alpha-1g

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.54   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 302   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.54   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 511

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8