Property Summary

NCBI Gene PubMed Count 25
Grant Count 511
R01 Count 308
Funding $111,539,748.33
PubMed Score 27956.43
PubTator Score 81.94

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (11)

Disease log2 FC p
Rheumatoid Arthritis 2.200 0.006
nephrosclerosis -1.727 0.048
malignant mesothelioma -7.600 0.000
osteosarcoma -5.545 0.000
cystic fibrosis -1.790 0.000
tuberculosis and treatment for 6 months -2.000 0.000
non-small cell lung carcinoma -1.200 0.000
lung cancer -3.200 0.000
lung adenocarcinoma -1.200 0.000
lung carcinoma -1.200 0.000
mucosa-associated lymphoid tissue lympho... 2.555 0.020

Synonym

Accession O43451 Q0VAX6 Q75ME7 Q86UM5
Symbols MG
MGA

Gene

PANTHER Protein Class (2)

PDB

2QLY   2QMJ   3CTT   3L4T   3L4U   3L4V   3L4W   3L4X   3L4Y   3L4Z   3TON   3TOP  

 GWAS Trait (1)

Gene RIF (14)

PMID Text
25776870 MGAM, or nearby regulatory elements, may be involved in the etiology of oral clefts.
25037326 Starch internal structure modulates its susceptibility to MGAM. The internal branch amounts negatively affect the glucose release rate.
23405089 The over-expression of MGAM was confirmed with a 6.6 fold increase in expression at the mRNA level whereas the fold change in ADAM9 demonstrated a 1.6 fold increase.
22563462 Findings suggest that C-terminal subunits of recombinant maltase-glucoamylase (MGAM) assists alpha-amylase in digesting starch molecules and potentially may compensate for developmental or pathological amylase deficiencies.
22058037 we report crystal structures of C-terminal maltase-glucoamylase alone at a resolution of 3.1 angstroms, and in complex with its inhibitor acarbose
22036121 These results suggest that the N-terminal and C-terminal catalytic domains of maltase-glucoamylase differ in their substrate specificities and inhibitor tolerance despite their structural relationship
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20356844 analysis of substrate selectivity of human maltase-glucoamylase and sucrase-isomaltase N-terminal domains
19913121 Observational study of gene-disease association. (HuGE Navigator)
19472353 This study reported the first diagnosed Finnish patient with a phenotype compatible with the late-onset form of Pompe disease. Molecular genetic analysis of the GAA gene revealed a novel missense mutation (Y575X),combined with (P545L) mutation.
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AA Sequence

MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTPDPGTTGTTHA      1 - 70
RTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHV     71 - 140
EGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAA    141 - 210
ASLTYQVEISRQPFSIKVTRRSNNRVLFDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNW    211 - 280
KTWPIFNRDTTPNGNGTNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYV    281 - 350
FLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADIDYMDER    351 - 420
RDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGE    421 - 490
VWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFTPRILD    491 - 560
GYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAAHWLGDNT    561 - 630
ATWDDLRWSIPGVLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFG    631 - 700
ADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVL    701 - 770
DEGAEKVMAYVPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGL    771 - 840
IIALDENKEAKGELFWDNGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFNEIKILGTEEP    841 - 910
SNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRDEEKIDCYPDENGASAENCTA    911 - 980
RGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADISLKSSVYANAFPSTPVNPLRLDVTYHKNEML    981 - 1050
QFKIYDPNKNRYEVPVPLNIPSMPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFI   1051 - 1120
RISTRLPSKYLYGFGETEHRSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNS   1121 - 1190
NAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIA   1191 - 1260
SLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAISGNETQPYPA   1261 - 1330
FTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEE   1331 - 1400
LYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGCRDASLNHPPYMPHLESRDRGLSSKTLCMESQQIL   1401 - 1470
PDGSLVQHYNVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIG   1471 - 1540
MMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDVAFVNISRTVLQ   1541 - 1610
TRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRA   1611 - 1680
RWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNTHLSRQKFMGFKIALDDEGTAGGWL   1681 - 1750
FWDDGQSIDTYGKGLYYLASFSASQNTMQSHIIFNNYITGTNPLKLGYIEIWGVGSVPVTSVSISVSGMV   1751 - 1820
ITPSFNNDPTTQVLSIDVTDRNISLHNFTSLTWISTL                                    1821 - 1857
//

Text Mined References (26)

PMID Year Title
25776870 2015 A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts.
25037326 2014 Branch pattern of starch internal structure influences the glucogenesis by mucosal Nt-maltase-glucoamylase.
24816252 2014 An atlas of genetic influences on human blood metabolites.
23966204 2014 GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
23568457 2013 Genetic variants associated with disordered eating.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23405089 2013 Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22563462 2012 Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal ?-glucosidase subunit.
22058037 2011 Structural insight into substrate specificity of human intestinal maltase-glucoamylase.
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