| Tclin | Maltase-glucoamylase, intestinal |
This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 58 |
| NCBI Gene PubMed Count | 25 |
| PubMed Score | 32564.43 |
| PubTator Score | 81.94 |
| Disease | Target Count |
|---|---|
| Diabetes mellitus type 2 | 69 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 3.3e-11 |
| malignant mesothelioma | 3232 | 1.9e-09 |
| lung adenocarcinoma | 2716 | 3.1e-09 |
| lung carcinoma | 2843 | 4.4e-05 |
| lung cancer | 4740 | 6.0e-05 |
| osteosarcoma | 7950 | 6.2e-05 |
| cystic fibrosis | 1696 | 6.6e-05 |
| tuberculosis | 2010 | 2.9e-03 |
| Rheumatoid arthritis | 1191 | 6.0e-03 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 2.0e-02 |
| nephrosclerosis | 333 | 4.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | -1.790 | 6.6e-05 |
| lung adenocarcinoma | -1.200 | 3.1e-09 |
| lung cancer | -3.000 | 6.0e-05 |
| lung carcinoma | -1.200 | 4.4e-05 |
| malignant mesothelioma | -7.600 | 1.9e-09 |
| mucosa-associated lymphoid tissue lympho... | 2.555 | 2.0e-02 |
| nephrosclerosis | -1.727 | 4.8e-02 |
| non-small cell lung cancer | -1.156 | 3.3e-11 |
| osteosarcoma | -5.545 | 6.2e-05 |
| Rheumatoid arthritis | 2.200 | 6.0e-03 |
| tuberculosis | -1.600 | 2.9e-03 |
CHEMBL121223
pKi 6.00
CHEMBL1208974
pKi 6.00
CHEMBL3814838
pIC50 6.02
CHEMBL330763
pKi 6.05
CHEMBL87169
pIC50 6.16
CHEMBL3814988
pIC50 6.16
CHEMBL2051760
pIC50 6.19
CHEMBL3814911
pIC50 6.19
CHEMBL3349440
pIC50 6.26
CHEMBL3349438
pIC50 6.28
CHEMBL1258644
pKi 6.30
CHEMBL3815109
pIC50 6.33
CHEMBL2115215
pKi 6.35
CHEMBL3349434
pIC50 6.39
CHEMBL307429
pIC50 6.44
CHEMBL3349446
pIC50 6.48
CHEMBL3349443
pIC50 6.57
CHEMBL3349433
pIC50 6.62
CHEMBL3349435
pIC50 6.64
CHEMBL1089559
pKi 6.70
MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTPDPGTTGTTHA 1 - 70 RTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHV 71 - 140 EGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAA 141 - 210 ASLTYQVEISRQPFSIKVTRRSNNRVLFDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNW 211 - 280 KTWPIFNRDTTPNGNGTNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYV 281 - 350 FLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADIDYMDER 351 - 420 RDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGE 421 - 490 VWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFTPRILD 491 - 560 GYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAAHWLGDNT 561 - 630 ATWDDLRWSIPGVLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFG 631 - 700 ADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVL 701 - 770 DEGAEKVMAYVPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGL 771 - 840 IIALDENKEAKGELFWDNGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFNEIKILGTEEP 841 - 910 SNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRDEEKIDCYPDENGASAENCTA 911 - 980 RGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADISLKSSVYANAFPSTPVNPLRLDVTYHKNEML 981 - 1050 QFKIYDPNKNRYEVPVPLNIPSMPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFI 1051 - 1120 RISTRLPSKYLYGFGETEHRSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNS 1121 - 1190 NAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIA 1191 - 1260 SLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAISGNETQPYPA 1261 - 1330 FTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEE 1331 - 1400 LYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGCRDASLNHPPYMPHLESRDRGLSSKTLCMESQQIL 1401 - 1470 PDGSLVQHYNVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIG 1471 - 1540 MMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDVAFVNISRTVLQ 1541 - 1610 TRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRA 1611 - 1680 RWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNTHLSRQKFMGFKIALDDEGTAGGWL 1681 - 1750 FWDDGQSIDTYGKGLYYLASFSASQNTMQSHIIFNNYITGTNPLKLGYIEIWGVGSVPVTSVSISVSGMV 1751 - 1820 ITPSFNNDPTTQVLSIDVTDRNISLHNFTSLTWISTL 1821 - 1857 //
