| Tclin | Maltase-glucoamylase, intestinal |
This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Diabetes mellitus type 2 | 69 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung carcinoma | 413 | 1.70334547503243E-15 |
| malignant mesothelioma | 3163 | 1.94666090597354E-9 |
| lung adenocarcinoma | 2714 | 3.1186761791103E-9 |
| lung cancer | 4473 | 2.34080904374682E-6 |
| lung carcinoma | 2844 | 4.41052000457691E-5 |
| osteosarcoma | 7933 | 6.24052559661076E-5 |
| cystic fibrosis | 1670 | 6.61328280668061E-5 |
| tuberculosis and treatment for 6 months | 686 | 4.71779754874467E-4 |
| Rheumatoid Arthritis | 1171 | 0.0060223893744557 |
| mucosa-associated lymphoid tissue lymphoma | 480 | 0.0198553356138223 |
| nephrosclerosis | 329 | 0.0484905651157127 |
| Disease | log2 FC | p |
|---|---|---|
| Rheumatoid Arthritis | 2.200 | 0.006 |
| nephrosclerosis | -1.727 | 0.048 |
| malignant mesothelioma | -7.600 | 0.000 |
| osteosarcoma | -5.545 | 0.000 |
| cystic fibrosis | -1.790 | 0.000 |
| tuberculosis and treatment for 6 months | -2.000 | 0.000 |
| non-small cell lung carcinoma | -1.200 | 0.000 |
| lung cancer | -3.200 | 0.000 |
| lung adenocarcinoma | -1.200 | 0.000 |
| lung carcinoma | -1.200 | 0.000 |
| mucosa-associated lymphoid tissue lympho... | 2.555 | 0.020 |
| Species | Source |
|---|---|
| Macaque | OMA EggNOG |
| Mouse | EggNOG Inparanoid |
| Rat | OMA EggNOG |
| Dog | OMA Inparanoid |
| Cow | OMA Inparanoid |
CHEMBL121223
pKi 6.00
CHEMBL1208974
pKi 6.00
CHEMBL3814838
pIC50 6.02
CHEMBL330763
pKi 6.05
CHEMBL87169
pIC50 6.16
CHEMBL3814988
pIC50 6.16
CHEMBL2051760
pIC50 6.19
CHEMBL3814911
pIC50 6.19
CHEMBL3349440
pIC50 6.26
CHEMBL3349438
pIC50 6.28
CHEMBL1258644
pKi 6.30
CHEMBL3815109
pIC50 6.33
CHEMBL2115215
pKi 6.35
CHEMBL3349434
pIC50 6.39
CHEMBL307429
pIC50 6.44
CHEMBL3349446
pIC50 6.48
CHEMBL3349443
pIC50 6.57
CHEMBL3349433
pIC50 6.62
CHEMBL3349435
pIC50 6.64
CHEMBL1089559
pKi 6.70
| PMID | Text |
|---|---|
| 25776870 | MGAM, or nearby regulatory elements, may be involved in the etiology of oral clefts. |
| 25037326 | Starch internal structure modulates its susceptibility to MGAM. The internal branch amounts negatively affect the glucose release rate. |
| 23405089 | The over-expression of MGAM was confirmed with a 6.6 fold increase in expression at the mRNA level whereas the fold change in ADAM9 demonstrated a 1.6 fold increase. |
| 22563462 | Findings suggest that C-terminal subunits of recombinant maltase-glucoamylase (MGAM) assists alpha-amylase in digesting starch molecules and potentially may compensate for developmental or pathological amylase deficiencies. |
| 22058037 | we report crystal structures of C-terminal maltase-glucoamylase alone at a resolution of 3.1 angstroms, and in complex with its inhibitor acarbose |
| 22036121 | These results suggest that the N-terminal and C-terminal catalytic domains of maltase-glucoamylase differ in their substrate specificities and inhibitor tolerance despite their structural relationship |
| 20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 20356844 | analysis of substrate selectivity of human maltase-glucoamylase and sucrase-isomaltase N-terminal domains |
| 19913121 | Observational study of gene-disease association. (HuGE Navigator) |
| 19472353 | This study reported the first diagnosed Finnish patient with a phenotype compatible with the late-onset form of Pompe disease. Molecular genetic analysis of the GAA gene revealed a novel missense mutation (Y575X),combined with (P545L) mutation. |
| More... |
MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTPDPGTTGTTHA 1 - 70 RTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHV 71 - 140 EGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAA 141 - 210 ASLTYQVEISRQPFSIKVTRRSNNRVLFDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNW 211 - 280 KTWPIFNRDTTPNGNGTNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYV 281 - 350 FLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADIDYMDER 351 - 420 RDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGE 421 - 490 VWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFTPRILD 491 - 560 GYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAAHWLGDNT 561 - 630 ATWDDLRWSIPGVLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFG 631 - 700 ADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVL 701 - 770 DEGAEKVMAYVPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGL 771 - 840 IIALDENKEAKGELFWDNGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFNEIKILGTEEP 841 - 910 SNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRDEEKIDCYPDENGASAENCTA 911 - 980 RGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADISLKSSVYANAFPSTPVNPLRLDVTYHKNEML 981 - 1050 QFKIYDPNKNRYEVPVPLNIPSMPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFI 1051 - 1120 RISTRLPSKYLYGFGETEHRSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNS 1121 - 1190 NAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIA 1191 - 1260 SLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAISGNETQPYPA 1261 - 1330 FTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEE 1331 - 1400 LYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGCRDASLNHPPYMPHLESRDRGLSSKTLCMESQQIL 1401 - 1470 PDGSLVQHYNVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIG 1471 - 1540 MMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDVAFVNISRTVLQ 1541 - 1610 TRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRA 1611 - 1680 RWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNTHLSRQKFMGFKIALDDEGTAGGWL 1681 - 1750 FWDDGQSIDTYGKGLYYLASFSASQNTMQSHIIFNNYITGTNPLKLGYIEIWGVGSVPVTSVSISVSGMV 1751 - 1820 ITPSFNNDPTTQVLSIDVTDRNISLHNFTSLTWISTL 1821 - 1857 //
| PMID | Year | Title |
|---|---|---|
| 25776870 | 2015 | A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts. |
| 25037326 | 2014 | Branch pattern of starch internal structure influences the glucogenesis by mucosal Nt-maltase-glucoamylase. |
| 24816252 | 2014 | An atlas of genetic influences on human blood metabolites. |
| 23966204 | 2014 | GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics. |
| 23568457 | 2013 | Genetic variants associated with disordered eating. |
| 23533145 | 2013 | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. |
| 23405089 | 2013 | Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9. |
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| 22563462 | 2012 | Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal ?-glucosidase subunit. |
| 22058037 | 2011 | Structural insight into substrate specificity of human intestinal maltase-glucoamylase. |
| More... |
