Tbio EIF4G3 Eukaryotic translation initiation factor 4 gamma 3

Protein Summary

Description

Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• O43432
• B9EGQ7
• Q15597
• Q504Z1
• Q5SWC3
• Q8NEN1
• eIF-4-gamma 3

Gene Name

• EIF4G3

Ensembl ID

• ENST00000264211
• ENSP00000264211
• ENSG00000075151
• ENST00000356916
• ENSP00000349386
• ENST00000374935
• ENSP00000364071
• ENST00000602326
• ENSP00000473510

Symbol

• eIF4G 3
• eIF4GII
• eIF-4G 3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
PubMedID	0.8
transcription factor	0.8
transcription factor perturbation	0.8
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4 Gamma 3

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4 Gamma 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.13   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 135   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.13   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0