Tbio HNRNPR Heterogeneous nuclear ribonucleoprotein R

Protein Summary

Description

Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• O43390
• Q2L7G6
• Q5TEH1
• Q9BV64
• S4R3J4
• hnRNP R

Gene Name

• HNRNPR

Ensembl ID

• ENST00000302271
• ENSP00000304405
• ENSG00000125944
• ENST00000374612
• ENSP00000363741
• ENST00000374616
• ENSP00000363745
• ENST00000427764
• ENSP00000392799
• ENST00000478691
• ENSP00000474437
• ENST00000634263
• ENSP00000489371
• ENSG00000282958
• ENST00000634634
• ENSP00000488941
• ENST00000634713
• ENSP00000488945
• ENST00000634766
• ENSP00000489252
• ENST00000635150
• ENSP00000489275

Symbol

• HNRPR
• HNRPR
• hnRNP-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
interacting protein	1
kinase perturbation	0.96
hub protein	0.88
transcription factor binding site profile	0.88

Protein Classes

PANTHER Classes

Protein / ... / Ribosomal Protein / Heterogeneous Nuclear Ribonucleoprotein R

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Heterogeneous Nuclear Ribonucleoprotein R

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.41   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.41   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0