Tchem RIPK2 Receptor-interacting serine/threonine-protein kinase 2

Protein Summary

Description

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43353
• B7Z748
• Q6UWF0

Gene Name

• RIPK2

Ensembl ID

• ENST00000220751
• ENSP00000220751
• ENSG00000104312

Symbol

• CARDIAK
• RICK
• RIP2
• CCK
• RICK
• RIP2
• CARD3
• GIG30
• CARDIAK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
drug perturbation	1
virus perturbation	1
molecular function	0.99
hub protein	0.95

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Ripk Family / Receptor-interacting Serine/threonine-protein Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.95   (req: < 5)

Gene RIFs: 103   (req: <= 3)

Antibodies: 608   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.95   (req: >= 5)

Gene RIFs: 103   (req: > 3)

Antibodies: 608   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 63

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 97

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5