Tbio CTIF CBP80/20-dependent translation initiation factor

Protein Summary

Description

Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

Uniprot Accession IDs

• O43310
• B3KTR8
• Q8IVD5

Gene Name

• CTIF

Ensembl ID

• ENST00000256413
• ENSP00000256413
• ENSG00000134030
• ENST00000382998
• ENSP00000372459
• ENST00000634350
• ENSP00000489354
• ENSG00000282825
• ENST00000635228
• ENSP00000489589

Symbol

• KIAA0427
• Gm672
• KIAA0427

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
transcription factor binding site profile	0.87
phenotype	0.69
PubMedID	0.66
transcription factor	0.64

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Cbp80/20-dependent Translation Initiation Factor

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Cbp80/20-dependent Translation Initiation Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.58   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.58   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0