Tchem MAP3K13 Mitogen-activated protein kinase kinase kinase 13

Protein Summary

Description

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43283
• B2R6U2
• B4DLE3
• B4DMV2
• B4DZJ4
• D3DNU1
• Q05BY6
• Q15450
• Q2NKN3

Gene Name

• MAP3K13

Ensembl ID

• ENST00000265026
• ENSP00000265026
• ENSG00000073803
• ENST00000424227
• ENSP00000399910
• ENST00000433092
• ENSP00000389798
• ENST00000438053
• ENSP00000403561
• ENST00000443863
• ENSP00000409325
• ENST00000446828
• ENSP00000411483

Symbol

• LZK
• LZK
• MLK
• MEKK13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
protein domain	0.85
virus perturbation	0.79
histone modification site profile	0.76
transcription factor perturbation	0.74

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Mlk Family / Lzk Subfamily / Mitogen-activated Protein Kinase Kinase Kinase 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.11   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.11   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0