Tbio ARHGAP6 Rho GTPase-activating protein 6

Protein Summary

Description

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43182
• B2RWQ0
• O43437
• Q9P1B3
• Q9UK81
• Q9UK82

Gene Name

• ARHGAP6

Ensembl ID

• ENST00000303025
• ENSP00000302312
• ENSG00000047648
• ENST00000337414
• ENSP00000338967
• ENST00000380718
• ENSP00000370094
• ENST00000380736
• ENSP00000370112
• ENST00000495242
• ENSP00000435767

Symbol

• RHOGAP6
• RHOGAP6
• RHOGAPX-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.78
cell type or tissue	0.74
transcription factor	0.72
cellular component	0.65
tissue sample	0.64

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Rho Gtpase-activating Protein 6

DTO Classes

Protein / Cellular Structure / Rho Gtpase-activating Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.73   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.73   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0