Tbio ST8SIA3 Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

Protein Summary

Description

Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O43173
• A8K0F2
• Q6B085
• Q9NS41

Gene Name

• ST8SIA3

Ensembl ID

• ENST00000324000
• ENSP00000320431
• ENSG00000177511

Symbol

• SIAT8C
• SIAT8C
• ST8SiaIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.86
pathway	0.85
disease perturbation	0.74
cell line	0.72
cell type or tissue	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.29   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.29   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0