Property Summary

NCBI Gene PubMed Count 24
PubMed Score 10.86
PubTator Score 5.93

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
breast carcinoma 1614 1.78906032008983E-24
ovarian cancer 8492 7.59702484605314E-18
astrocytoma 1493 3.28480856064397E-11
Breast cancer 3099 3.58022171916288E-11
malignant mesothelioma 3163 1.3017908288423E-9
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.63087071398141E-7
intraductal papillary-mucinous neoplasm (IPMN) 3289 9.73893053618638E-7
juvenile dermatomyositis 1189 1.42861238221671E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 3.43278932003001E-6
Pick disease 1893 1.60875608763621E-5
invasive ductal carcinoma 2950 2.11555087497814E-4
colon cancer 1475 2.62854587713112E-4
cystic fibrosis 1670 3.74515369578014E-4
group 4 medulloblastoma 1875 0.00120460600768748
tuberculosis 1563 0.00142859269011705
glioblastoma 5572 0.0028334153040475
pancreatic cancer 2300 0.00287445914631854
pediatric high grade glioma 2712 0.00684536330177911
ulcerative colitis 2087 0.00712713580875281
ependymoma 2514 0.0112260119071943
oligodendroglioma 2849 0.0127898689508331
osteosarcoma 7933 0.0223191234009217
hereditary spastic paraplegia 313 0.0492982720997257
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0

Expression

  Differential Expression (23)

Disease log2 FC p
malignant mesothelioma -4.100 0.000
astrocytoma -1.500 0.000
ependymoma -3.000 0.011
oligodendroglioma -2.100 0.013
glioblastoma -2.500 0.003
osteosarcoma -1.835 0.022
cystic fibrosis 1.190 0.000
hereditary spastic paraplegia -1.009 0.049
juvenile dermatomyositis 1.048 0.000
tuberculosis -1.100 0.001
intraductal papillary-mucinous adenoma (... -5.000 0.000
intraductal papillary-mucinous carcinoma... -5.900 0.000
intraductal papillary-mucinous neoplasm ... -6.000 0.000
colon cancer -1.700 0.000
pancreatic cancer -1.400 0.003
pediatric high grade glioma -1.800 0.007
group 4 medulloblastoma -2.600 0.001
breast carcinoma -1.500 0.000
Pick disease 1.900 0.000
Breast cancer -1.800 0.000
invasive ductal carcinoma -2.800 0.000
ulcerative colitis 1.200 0.007
ovarian cancer -6.300 0.000

Synonym

Accession O43155 A0AV84 B7ZLP3
Symbols

Gene

  Ortholog (13)

Gene RIF (3)

PMID Text
24732660 PCMC expression of ADAM29, FLRT2, and SLC18A3 could be assessed as part of a routine screen to help identify individuals at risk of severe Obstructive sleep apnea in Asian populations
22747982 The membrane protein, FLRT2, was identified as a novel autoantigen in systemic lupus erythematosus patients.
19834535 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYL      1 - 70
HNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHL     71 - 140
DDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLI    141 - 210
VDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLER    211 - 280
LDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAV    281 - 350
RELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPP    351 - 420
ISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYR    421 - 490
ICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLS    491 - 560
VFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTP    561 - 630
NGGINYTDCHIPNNMRYCNSSVPDLEHCHT                                            631 - 660
//

Text Mined References (25)

PMID Year Title
27091502 2016 Super-complexes of adhesion GPCRs and neural guidance receptors.
26890304 2016 Methylation profiling identified novel differentially methylated markers including OPCML and FLRT2 in prostate cancer.
26633812 2015 An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.
25728924 2015 Structural basis of latrophilin-FLRT interaction.
24732660 Gene expression profiles in peripheral blood mononuclear cells of Asian obstructive sleep apnea patients.
23720494 2013 Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
23599027 2013 Genome-wide association study of age at menarche in African-American women.
23583979 2013 Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
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