| Tbio | Regulator of G-protein signaling 5 |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
Comments
| Disease | Target Count |
|---|---|
| Essential Hypertension | 82 |
| Hypertensive disease | 193 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Benign paroxysmal positional nystagmus | 13 | 3.177 | 1.6 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA EggNOG |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26782409 | The rs16849802 of RGS5 and haplotype GAA independently increased the risk of essential hypertension in Mongolian patients, and may be used as a risk factor for the prediction of high blood pressure. |
| 26663397 | Downregulation of RGS5 is an important prerequisite for smooth muscle cell proliferation in vascular injury model. |
| 26558691 | The pericyte marker RGS5 may be of future clinical utility for the evaluation of pericytic differentiation in soft tissue tumors. |
| 25891540 | RGS5 enhanced the cytotoxic effect of radiation in the human lung cancer cells. Our results indicated that RGS5 may be a potential target for cancer therapy. |
| 24297163 | ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected. |
| 23868206 | Over-expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma cells. |
| 23464602 | RGS1 is largely upregulated, whereas RGS2 is downregulated in the majority of solid tumors, whereas RGS5 transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies |
| 23193110 | Our work identifies a new genetic variant in RGS5 demonstrating additive effect with PDE4D, both implicated in modulation of asthma treatment. |
| 22130514 | demonstrate RGS5 in the blood vessels of other cancer models endowed with a proangiogenic environment, such as human melanoma and renal carcinoma xenografts |
| 21881522 | examined polymorphisms in three genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26782409 | 2015 | Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations. |
| 26663397 | 2016 | Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation. |
| 26558691 | 2016 | The pericyte antigen RGS5 in perivascular soft tissue tumors. |
| 25891540 | 2015 | Overexpression of the regulator of G-protein signaling 5 reduces the survival rate and enhances the radiation response of human lung cancer cells. |
| 24297163 | 2014 | Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. |
| 24124411 | 2013 | Genome-wide association study of liver enzymes in korean children. |
| 24009623 | 2013 | Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. |
| 23868206 | 2013 | Over-expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma cells. |
| 23464602 | 2013 | RGS expression in cancer: oncomining the cancer microarray data. |
| 23193110 | 2013 | RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients. |
| More... |
