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  5. Regulator of G-protein signaling 5

Tbio Regulator of G-protein signaling 5

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).

This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

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Property Summary

NCBI Gene PubMed Count 54
PubMed Score 49.28
PubTator Score 52.84

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Benign paroxysmal positional nystagmus 11 3.053 1.5

Expression

  Differential Expression (36)

Disease log2 FC p
acute myeloid leukemia -1.700 4.7e-02
adult high grade glioma -1.700 3.7e-03
aldosterone-producing adenoma -1.805 3.4e-02
astrocytic glioma -1.200 2.5e-02
atypical teratoid / rhabdoid tumor 1.500 1.4e-09
breast carcinoma -1.100 1.3e-12
colon cancer -1.500 4.8e-02
cystic fibrosis and chronic rhinosinusit... 1.005 2.5e-02
dermatomyositis -1.500 2.3e-03
Down syndrome 1.200 1.8e-02
glioblastoma -2.000 6.1e-03
group 3 medulloblastoma 1.400 4.0e-03
group 4 medulloblastoma -1.200 1.5e-02
interstitial cystitis 1.300 3.0e-03
intraductal papillary-mucinous adenoma (... -2.500 1.6e-02
intraductal papillary-mucinous carcinoma... -1.700 2.6e-02
intraductal papillary-mucinous neoplasm ... -3.900 3.0e-03
invasive ductal carcinoma -1.100 7.0e-04
lung adenocarcinoma -1.100 2.1e-06
lung cancer -1.200 1.7e-03
lung carcinoma 2.000 7.3e-13
medulloblastoma, large-cell -1.700 4.2e-03
non-small cell lung cancer -1.064 2.3e-06
osteosarcoma 2.530 5.5e-03
ovarian cancer -2.700 5.4e-06
pancreatic cancer 1.300 9.9e-03
pituitary cancer 2.500 1.6e-03
posterior fossa group B ependymoma 1.500 1.9e-06
primary pancreatic ductal adenocarcinoma 1.260 4.5e-02
primary Sjogren syndrome 1.400 2.0e-03
primitive neuroectodermal tumor 1.200 2.5e-04
psoriasis 1.600 1.1e-02
pterygium 2.000 1.2e-03
type 2 diabetes -1.055 6.6e-03
ulcerative colitis 2.100 9.2e-05
urothelial carcinoma 3.100 4.5e-05

Synonym

Accession O15539 E9PMP5 Q53XA9 Q599J0 RGS5
Symbols MST092
MST106
MST129
MSTP032
MSTP092
MSTP106
MSTP129

Gene

RGS5

PANTHER Protein Class (2)

  Ortholog (12)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (7)

 GO Function (1)

 GO Component (3)

 GO Process (2)

 Compartment GO Term (11)

 MGI Phenotype (9)

 GWAS Trait (4)

 HCA RNA Cell Line (55)

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Pathway (13)

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Protein-protein Interaction (2)

CST8   OMP  

PDB (1)

Gene RIF (38)

AA Sequence 

MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQ      1 - 70
NNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITM     71 - 140
KNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK                                 141 - 181
//

Text Mined References (55)

PMID Year Title