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Tdark
GPR42
G-protein coupled receptor 42

Protein Summary
Description
Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000454971
  • ENSP00000410925
  • ENSG00000126251
  • ENST00000597214
  • ENSP00000473212

Symbol
  • GPR42P
  • FFAR1L
  • FFAR3L
  • GPR41L
  • GPR42P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.34
tissue
0.32
disease perturbation
0.25
PubMedID
0.17
small molecule perturbation
0.15


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.93   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.93   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0