Tbio SOCS1 Suppressor of cytokine signaling 1

Protein Summary

Description

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15524
• O15097
• Q9NSA7
• SOCS-1

Gene Name

• SOCS1

Ensembl ID

• ENST00000332029
• ENSP00000329418
• ENSG00000185338
• ENST00000644787
• ENSP00000496577

Symbol

• SSI1
• TIP3
• JAB
• CIS1
• SSI1
• TIP3
• CISH1
• SSI-1
• TIP-3
• SOCS-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
biological term	0.98
hub protein	0.98
transcription factor binding site profile	0.91
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Suppressor Of Cytokine Signaling 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1083.29   (req: < 5)

Gene RIFs: 380   (req: <= 3)

Antibodies: 567   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1083.29   (req: >= 5)

Gene RIFs: 380   (req: > 3)

Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0