Tdark MAGEB3 Melanoma-associated antigen B3

Protein Summary

Description

This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15480
• A0AVE4
• B3KQ52
• O75861

Gene Name

• MAGEB3

Ensembl ID

• ENST00000361644
• ENSP00000355198
• ENSG00000198798
• ENST00000620842
• ENSP00000478513

Symbol

• CT3.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.59
cell type or tissue	0.52
cellular component	0.52
tissue sample	0.37
cell line	0.36

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Melanoma-associated Antigen B3

DTO Classes

Protein / Cell Adhesion / Melanoma-associated Antigen B3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.71   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.71   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0