Tchem ABCC5 Multidrug resistance-associated protein 5

Protein Summary

Description

Acts as a multispecific organic anion pump which can transport nucleotide analogs. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• O15440
• B9EIQ2
• O14517
• Q29ZA9
• Q29ZB1
• Q86UX3
• Q86W30
• Q9UN85
• Q9UNP5
• Q9UQC3

Gene Name

• ABCC5

Ensembl ID

• ENST00000265586
• ENSP00000265586
• ENSG00000114770
• ENST00000334444
• ENSP00000333926
• ENST00000382494
• ENSP00000371934
• ENST00000392579
• ENSP00000376358
• ENST00000443376
• ENSP00000416840

Symbol

• MRP5
• MRP5
• SMRP
• ABC33
• MOATC
• MOAT-C
• pABC11
• EST277145

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
transcription factor perturbation	0.98
disease perturbation	0.95
transcription factor binding site profile	0.94
kinase perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Multidrug Resistance-associated Protein 5

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcc Subfamily / Multidrug Resistance-associated Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.36   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 359   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.36   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1