Tchem ABCC4 Multidrug resistance-associated protein 4

Protein Summary

Description

May be an organic anion pump relevant to cellular detoxification. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• O15439
• A9Z1Z7
• B7Z3Q7
• Q8IVZ4
• Q8IZN6
• Q8NEW8
• Q9Y6J2

Gene Name

• ABCC4

Ensembl ID

• ENST00000376887
• ENSP00000366084
• ENSG00000125257
• ENST00000536256
• ENSP00000442024
• ENST00000629385
• ENSP00000487081
• ENST00000645237
• ENSP00000494609
• ENST00000646439
• ENSP00000494751

Symbol

• MRP4
• MRP4
• MOATB
• MOAT-B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	0.99
molecular function	0.99
chemical	0.96
trait	0.93
transcription factor binding site profile	0.91

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Multidrug Resistance-associated Protein 4

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcc Subfamily / Multidrug Resistance-associated Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.99   (req: < 5)

Gene RIFs: 169   (req: <= 3)

Antibodies: 432   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.99   (req: >= 5)

Gene RIFs: 169   (req: > 3)

Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0