| Tbio | Eukaryotic translation initiation factor 3 subunit H |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma, Hepatocellular | 228 | 0.0 | 0.0 |
| Colorectal Neoplasms | 243 | 0.0 | 0.0 |
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Liver carcinoma | 240 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 5.1e-05 |
| cystic fibrosis | 1696 | 9.4e-05 |
| Multiple myeloma | 1332 | 1.1e-04 |
| lung cancer | 4740 | 2.2e-04 |
| group 4 medulloblastoma | 1855 | 3.4e-03 |
| Waldenstrons macroglobulinemia | 765 | 3.9e-03 |
| nasopharyngeal carcinoma | 1058 | 1.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Breast cancer | 3578 | 0.0 | 2.2 |
| Cardiovascular system disease | 246 | 0.0 | 1.4 |
| Globe disease | 67 | 0.0 | 0.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Trichorhinophalangeal syndrome type II | 15 | 4.363 | 2.2 |
| Trichorhinophalangeal syndrome type I | 8 | 3.905 | 2.0 |
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | -1.400 | 9.4e-05 |
| group 4 medulloblastoma | -1.100 | 3.4e-03 |
| lung cancer | 1.600 | 2.2e-04 |
| Multiple myeloma | 1.648 | 1.1e-04 |
| nasopharyngeal carcinoma | 1.200 | 1.9e-02 |
| ovarian cancer | -1.600 | 5.1e-05 |
| Waldenstrons macroglobulinemia | 1.143 | 3.9e-03 |
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGL 1 - 70 VVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSY 71 - 140 QHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHL 141 - 210 INVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQR 211 - 280 RQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEY 281 - 350 NN 351 - 352 //
