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  4. Class C metabotropic glutamate-pheromone
  5. Metabotropic glutamate receptor
  6. Metabotropic glutamate receptor 6

Tchem Metabotropic glutamate receptor 6

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]

 Comments

Property Summary

Ligand Count 19
NCBI Gene PubMed Count 22
PubMed Score 92.30
PubTator Score 22.76

Knowledge Summary

Patent (5,257)

TINX Plot

  Disease (7)

Disease Target Count Z-score Confidence
Night blindness, congenital stationary 16 0.0 0.0
Disease Target Count P-value
psoriasis 6694 1.2e-22
medulloblastoma, large-cell 6241 9.8e-04
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.2
Kidney cancer 2613 0.0 0.5
Liver cancer 604 0.0 0.5
lung cancer 4740 0.0 0.5
Disease Target Count Z-score Confidence
Congenital stationary night blindness 1B 6 0.0 5.0
Disease Target Count Z-score Confidence
Suppression amblyopia 8 3.558 1.8
Retinal Degeneration 106 3.25 1.6

Expression

  Differential Expression (2)

Disease log2 FC p
medulloblastoma, large-cell 1.100 9.8e-04
psoriasis -1.700 1.2e-22

Synonym

Accession O15303 mGluR6
Symbols mGlu6
CSNB1B
GPRC1F
MGLUR6

Gene

GRM6

PANTHER Protein Class (2)

  Ortholog (11)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA

 UniProt Keyword (20)

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 GO Function (4)

 GO Component (7)

 GO Process (10)

 Compartment GO Term (48)

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 IMPC Phenotype (8)

 OMIM Phenotype (1)

 MGI Phenotype (4)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (24)

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Ligand (19)

Structure of homo-AMPA

homo-AMPA
pEC50 4.10

Structure of L-glutamic acid

L-glutamic acid
- 4.80

Structure of LSP1-2111

LSP1-2111
pEC50 5.77

Structure of LSP4-2022

LSP4-2022
pEC50 5.36

Structure of 1-benzyl-APDC

1-benzyl-APDC
- 4.70

Structure of IUPHAR1365

(1S,3R)-ACPD
4.70

Structure of ACPT-I

ACPT-I
4.70

Structure of eglumegad

eglumegad
5.50

Structure of IUPHAR1406

(R,S)-4-PPG
5.30

Structure of IUPHAR1407

(S)-3,4-DCPG
pEC50 5.40

Structure of L-CCG-I

L-CCG-I
- 5.20

Structure of L-serine-O-phosphate

L-serine-O-phosphate
- 6.40

Structure of LY379268

LY379268
6.40

Structure of PHCCC

PHCCC
pEC50 4.80

Structure of α-methylserine-O-phosphate

α-methylserine-O-phosphate
4.10

Structure of DCG-IV

DCG-IV
5.60

Structure of MAP4

MAP4
- 3.50

Structure of MPPG

MPPG
3.30

Structure of IUPHAR1399

[3H]LY341495
4.50

Gene RIF (19)

AA Sequence 

MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLE      1 - 70
AMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPA     71 - 140
PPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRA    141 - 210
LGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFA    211 - 280
NEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLEN    281 - 350
NRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ    351 - 420
ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAV    421 - 490
GQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPG    491 - 560
DMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTG    561 - 630
IFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVI    631 - 700
TFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAI    701 - 770
KARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT    771 - 840
YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK                                     841 - 877
//

Text Mined References (24)

PMID Year Title