Property Summary

NCBI Gene PubMed Count 12
PubMed Score 36.41
PubTator Score 35.90

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
pediatric high grade glioma 2712 1.67428848016078E-6
ovarian cancer 8492 4.265999360315E-6
Multiple myeloma 1328 7.65790436239147E-5
psoriasis 6685 1.74934646821701E-4
glioblastoma 5572 5.06842344873551E-4
dermatomyositis 967 0.00119031632191573
non primary Sjogren syndrome sicca 840 0.0216772586448564


  Differential Expression (7)

Disease log2 FC p
Multiple myeloma 1.224 0.000
psoriasis -1.800 0.000
glioblastoma 1.700 0.001
pediatric high grade glioma 1.100 0.000
non primary Sjogren syndrome sicca 1.200 0.022
ovarian cancer 2.400 0.000
dermatomyositis 1.200 0.001


Accession O15258 O95322


  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (7)

25385046 Charcot-Marie-Tooth disease-related PMP22 is trapped in the endoplasmic reticulum by calnexin-dependent retention and Rer1-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system.
25096327 Rer1p regulates the ER retention of immature or misfolded rhodopsin and modulates its intracellular trafficking through the early secretory pathway.
23479743 Rer1p depletion reduced ciliary length and function by increasing gamma-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression.
23129766 Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1, for degradation.
23043097 RER1 modulates amyloid-beta production by altering trafficking of gamma-secretase and amyloid precursor protein.
22190034 HIV-1 gp41 is identified to have a physical interaction with retention in endoplasmic reticulum 1 homolog (RER1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
17668005 Downregulation of Rer1 leads to increased surface localization of Pen2, whereas overexpression of Rer1 stabilizes unassembled Pen2. Rer1 is the first identified interaction partner of mammalian transmembrane-based retention/retrieval signals.

AA Sequence


Text Mined References (23)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25385046 2014 Rer1 and calnexin regulate endoplasmic reticulum retention of a peripheral myelin protein 22 mutant that causes type 1A Charcot-Marie-Tooth disease.
25096327 2014 Rer1p regulates the ER retention of immature rhodopsin and modulates its intracellular trafficking.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23479743 2013 Rer1p maintains ciliary length and signaling by regulating ?-secretase activity and Foxj1a levels.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23129766 2012 The ubiquitin ligase synoviolin up-regulates amyloid ? production by targeting a negative regulator of ?-secretase, Rer1, for degradation.
23043097 2012 Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-? (A?) production by altering trafficking of ?-secretase and amyloid precursor protein (APP).
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.