Tbio PFDN6 Prefoldin subunit 6

Protein Summary

Description

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]

Uniprot Accession IDs

• O15212

Gene Name

• PFDN6

Ensembl ID

• ENST00000374606
• ENSP00000363734
• ENSG00000204220
• ENST00000374607
• ENSP00000363735
• ENST00000374610
• ENSP00000363738
• ENST00000383207
• ENSP00000372694
• ENSG00000206283
• ENST00000395131
• ENSP00000378563
• ENST00000399383
• ENSP00000382314
• ENST00000399385
• ENSP00000382316
• ENST00000412289
• ENSP00000402212
• ENSG00000224782
• ENST00000425878
• ENSP00000395462
• ENST00000431830
• ENSP00000402553
• ENSG00000235692
• ENST00000432391
• ENSP00000400152
• ENST00000442285
• ENSP00000404773
• ENST00000445559
• ENSP00000398171
• ENSG00000237335
• ENST00000448594
• ENSP00000403771
• ENST00000451970
• ENSP00000415678
• ENST00000452658
• ENSP00000412319
• ENST00000547641
• ENSP00000449925
• ENST00000547952
• ENSP00000448784
• ENST00000548040
• ENSP00000447540
• ENST00000552711
• ENSP00000448607

Symbol

• HKE2
• PFD6
• HKE2
• KE-2
• PFD6
• H2-KE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
transcription factor perturbation	0.61
tissue sample	0.6
interacting protein	0.52
cell line	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.46   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.46   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0