Property Summary

NCBI Gene PubMed Count 38
PubMed Score 14.82
PubTator Score 7.35

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
ulcerative colitis 2087
Disease Target Count P-value
ovarian cancer 8492 9.67799890826057E-7
intraductal papillary-mucinous adenoma (IPMA) 2956 3.67890046706373E-4
Multiple myeloma 1328 0.00134740140454894
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00673786104893659
pancreatic cancer 2300 0.00727702433838228
primary pancreatic ductal adenocarcinoma 1271 0.00984376479944915
Waldenstrons macroglobulinemia 765 0.0385111321879575
lung cancer 4473 0.042606318598394



Accession O15144 Q92801 Q9P1D4
Symbols ARC34


  Ortholog (15)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid
C. elegans OMA Inparanoid
Fruitfly EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (14)

25260753 FOXF1 repressed cell growth and expression of collagen-1 and actin-related protein 2/3 complex, subunit 2.
24621569 Recent reports now demonstrate a novel aspect of the ARP2/3 complex and the nucleating-promoting factors in the maintenance of endothelial barrier function and junction remodeling of established endothelial cell junctions.
23119100 M-tropic HIV-1 gp120 enhances the binding of WASp and the actin-related protein 2/3 complex with beta-actin, an interaction essential for the proper formation of podosomes in immature monocyte-derived dendritic cells
22188208 The Arp2/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion.
21975549 Filopodia initiation: focus on the Arp2/3 complex and formins
21251247 Endogenous Nogo-B, which may exert its effects through ARPC 2/3 and MYL-9, is necessary for the migration and contraction of airway smooth muscle cells.
20974812 The results identify Arp2/3 complex as a key factor in the generation of the dynamic actin cluster during mitosis.
20308062 WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
19861958 Observational study of gene-disease association. (HuGE Navigator)
18836448 These findings strongly suggest that defective IL10 function is central to the pathogenesis of the ulcerative colitis subtype of inflammatory bowel disease.

AA Sequence

RPDAEKKEMKTITGKTFSSR                                                      281 - 300

Text Mined References (43)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25260753 2014 Forkhead Box F1 represses cell growth and inhibits COL1 and ARPC2 expression in lung fibroblasts in vitro.
24621569 2014 Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22188208 2012 Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway.