| Tbio | Calmegin |
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).
Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Male infertility | 170 | 3.745 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -1.800 | 0.000 |
| group 3 medulloblastoma | 3.200 | 0.000 |
| cystic fibrosis | 4.327 | 0.000 |
| medulloblastoma, large-cell | 2.100 | 0.000 |
| primitive neuroectodermal tumor | 1.400 | 0.018 |
| adrenocortical carcinoma | 1.863 | 0.013 |
| non-small cell lung cancer | 1.134 | 0.000 |
| Hydrolethalus syndrome | -1.191 | 0.028 |
| breast carcinoma | 1.400 | 0.001 |
| pilocytic astrocytoma | -1.600 | 0.000 |
| posterior fossa group B ependymoma | 1.500 | 0.002 |
| subependymal giant cell astrocytoma | -1.488 | 0.040 |
| Endometriosis | -1.034 | 0.045 |
| lung carcinoma | 2.400 | 0.000 |
| Breast cancer | 1.700 | 0.002 |
| mucosa-associated lymphoid tissue lympho... | -1.159 | 0.011 |
| ductal carcinoma in situ | 2.700 | 0.006 |
| invasive ductal carcinoma | 4.400 | 0.001 |
| acute myeloid leukemia | -2.300 | 0.031 |
| pituitary cancer | -1.100 | 0.001 |
| chronic rhinosinusitis | -1.157 | 0.046 |
| psoriasis | -1.600 | 0.000 |
| Species | Source |
|---|---|
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA Inparanoid |
| C. elegans | OMA Inparanoid |
| Fruitfly | EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 24769397 | Although their similarity in carbohydrate binding specificities is high, there seems to be some differences in the mode of substrate recognition between calmegin and calnexin. |
| 22190034 | HIV-1 gp120 is identified to have a physical interaction with calmegin (CLGN) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 16264275 | calmegin expression is regulated by histone deacetylase and CpG methyltransferase in a coordinative way |
MHFQAFWLCLGLLFISINAEFMDDDVETEDFEENSEEIDVNESELSSEIKYKTPQPIGEVYFAETFDSGR 1 - 70 LAGWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLAKPFIFADKPLIVQ 71 - 140 YEVNFQDGIDCGGAYIKLLADTDDLILENFYDKTSYIIMFGPDKCGEDYKLHFIFRHKHPKTGVFEEKHA 141 - 210 KPPDVDLKKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDE 211 - 280 RAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPA 281 - 350 CRIGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTS 351 - 420 DIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTAGVPIALITSF 421 - 490 CWPRKVKKKHKDTEYKKTDICIPQTKGVLEQEEKEEKAALEKPMDLEEEKKQNDGEMLEKEEESEPEEKS 491 - 560 EEEIEIIEGQEESNQSNKSGSEDEMKEADESTGSGDGPIKSVRKRRVRKD 561 - 610 //
| PMID | Year | Title |
|---|---|---|
| 24769397 | 2014 | Glycan specificity of a testis-specific lectin chaperone calmegin and effects of hydrophobic interactions. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 17903293 | 2007 | Genome-wide association with select biomarker traits in the Framingham Heart Study. |
| 17507649 | 2007 | A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells. |
| 17081983 | 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |
| 16264275 | 2005 | Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| More... |
