| Tbio | Calmegin |
Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).
Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 8.1e-21 |
| lung carcinoma | 2843 | 5.6e-20 |
| cystic fibrosis | 1696 | 1.7e-08 |
| malignant mesothelioma | 3232 | 9.9e-06 |
| group 3 medulloblastoma | 4104 | 1.8e-05 |
| medulloblastoma, large-cell | 6241 | 5.3e-05 |
| non-small cell lung cancer | 2890 | 5.6e-05 |
| Astrocytoma, Pilocytic | 3081 | 3.4e-04 |
| invasive ductal carcinoma | 2951 | 8.6e-04 |
| pituitary cancer | 1972 | 1.0e-03 |
| breast carcinoma | 1638 | 1.1e-03 |
| posterior fossa group B ependymoma | 416 | 1.8e-03 |
| Breast cancer | 3578 | 2.4e-03 |
| ductal carcinoma in situ | 1745 | 5.9e-03 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 1.1e-02 |
| adrenocortical carcinoma | 1428 | 1.3e-02 |
| primitive neuroectodermal tumor | 3035 | 1.8e-02 |
| Hydrolethalus syndrome | 128 | 2.8e-02 |
| acute myeloid leukemia | 783 | 3.1e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.0e-02 |
| Endometriosis | 540 | 4.5e-02 |
| chronic rhinosinusitis | 512 | 4.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Male infertility | 206 | 3.739 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -2.300 | 3.1e-02 |
| adrenocortical carcinoma | 1.863 | 1.3e-02 |
| Astrocytoma, Pilocytic | -1.600 | 3.4e-04 |
| Breast cancer | 1.700 | 2.4e-03 |
| breast carcinoma | 1.400 | 1.1e-03 |
| chronic rhinosinusitis | -1.157 | 4.6e-02 |
| cystic fibrosis | 4.327 | 1.7e-08 |
| ductal carcinoma in situ | 2.700 | 5.9e-03 |
| Endometriosis | -1.034 | 4.5e-02 |
| group 3 medulloblastoma | 3.200 | 1.8e-05 |
| Hydrolethalus syndrome | -1.191 | 2.8e-02 |
| invasive ductal carcinoma | 4.400 | 8.6e-04 |
| lung carcinoma | 2.400 | 5.6e-20 |
| malignant mesothelioma | -1.800 | 9.9e-06 |
| medulloblastoma, large-cell | 2.100 | 5.3e-05 |
| mucosa-associated lymphoid tissue lympho... | -1.159 | 1.1e-02 |
| non-small cell lung cancer | 1.134 | 5.6e-05 |
| pituitary cancer | -1.100 | 1.0e-03 |
| posterior fossa group B ependymoma | 1.500 | 1.8e-03 |
| primitive neuroectodermal tumor | 1.400 | 1.8e-02 |
| psoriasis | -1.600 | 8.1e-21 |
| subependymal giant cell astrocytoma | -1.488 | 4.0e-02 |
MHFQAFWLCLGLLFISINAEFMDDDVETEDFEENSEEIDVNESELSSEIKYKTPQPIGEVYFAETFDSGR 1 - 70 LAGWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLAKPFIFADKPLIVQ 71 - 140 YEVNFQDGIDCGGAYIKLLADTDDLILENFYDKTSYIIMFGPDKCGEDYKLHFIFRHKHPKTGVFEEKHA 141 - 210 KPPDVDLKKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDE 211 - 280 RAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPA 281 - 350 CRIGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTS 351 - 420 DIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTAGVPIALITSF 421 - 490 CWPRKVKKKHKDTEYKKTDICIPQTKGVLEQEEKEEKAALEKPMDLEEEKKQNDGEMLEKEEESEPEEKS 491 - 560 EEEIEIIEGQEESNQSNKSGSEDEMKEADESTGSGDGPIKSVRKRRVRKD 561 - 610 //
